Protein Info for BT2391 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1377 transmembrane" amino acids 7 to 29 (23 residues), see Phobius details amino acids 790 to 812 (23 residues), see Phobius details PF07494: Reg_prop" amino acids 42 to 65 (24 residues), 18.6 bits, see alignment (E = 5.5e-07) amino acids 365 to 386 (22 residues), 15.6 bits, see alignment (E = 5e-06) amino acids 506 to 523 (18 residues), 17.7 bits, see alignment (E = 1.1e-06) PF07495: Y_Y_Y" amino acids 728 to 783 (56 residues), 39.3 bits, see alignment (E = 1.7e-13) PF00512: HisKA" amino acids 845 to 910 (66 residues), 31.2 bits, see alignment 6.3e-11 PF02518: HATPase_c" amino acids 957 to 1069 (113 residues), 75.5 bits, see alignment E=1.6e-24 PF00072: Response_reg" amino acids 1127 to 1237 (111 residues), 89 bits, see alignment E=8.3e-29 PF12833: HTH_18" amino acids 1294 to 1372 (79 residues), 59 bits, see alignment 1.6e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_2391)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A551 at UniProt or InterPro

Protein Sequence (1377 amino acids)

>BT2391 two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKRTVRYTVLVLIAIINSLVITTSLYAVLPYNELHQLNMSNGLVDNIITCIYQDQDRFMW
FGSTNGLSRYDGKQIRNFSVDNARMYVSDIKETSDDKLWVITNEYLYCFDRRKEKFVLPS
FQDGKKAISVSAMEITGDSLFWIVKGGQLQCLKRHYKLVKGDLQIEMTVEAGYPFFLDEG
ESFSNLCASQDGHFLYLVTDKGNLLFFDKIAGKVVRKFKYSINPSANATTIMSEGEYIWI
SSIVGGVTRLHIPTGKSDYYQYNEDARLSSLSHSDAYGVVALDNDSYIAVTWNGYTLLAP
EENDPSKLSATPYTNTSFLQYRNVETRMISVYYDKEGILWIGTRGGGIVYFDFRQHSYMQ
YHSKKHNEISAQVADKDGRIWLGTYHEGIMRSDQPYAKSRPLNFSPVGNQKEVPVFCATK
DSCSNLWFGNASGNLICYDWSSDSFHIYPLNYLGKKVNSYIVALMIDTRYRFWVCTSAGL
YLFDRQTGHFELFSLREALKEDAEPWVTAICEDKQRNIWIGTAKGIVRLSQVNVRPLKMV
HGYEEKENIGARVVSALLTGTDGTVYVGYKNGFGIIPVGEDRIASFYTVKDGLCNDCIDC
IVEDEKKRIWLGSISGISRYSRQQHVFYNYYISSSNKSVMLFKNTLFWGNNKSLTYFEPE
ILTSATIASKTLLTGLEVDNKPINIGEKIKGQVVLDSNIASIDHLELVNANRDFSLLFNN
LAFSKDLQKYSYRLYPYQKDWIVSEAGKVSFTNLSAGYYIFEVKTLFPNNTEGDVTALPI
TILPHWSQTVWFRLLLIFSVLFLVGYIFYSLLRRQRRFKKMIQLKHELTIANLERNAERH
IREERENFFMNAAHELRTPLTLILAPIHDIMKSITPSDNWFDSFSRLHKNCLSLQTLVDR
LLYVQKIEGGMIKLHLSESDIKEIVSRVANPFLQMAMVKKREFLVQVDTVPLYLWVDVAK
IESAVQNLLSNAFKYTSQNGRIELAVSEAEIDGRPYCLVTVSDNGVGIPDDLQQHVFDSF
VTGKRIPQYSTSIGLGLHIVKHTMGLHHGFVTLTSRVGEGSRFVLHIPVGLSHFAQGEYE
MVPDPMKGDLLEECPAEERPMEEVVEEKNETMEEAVNRVKNNKEYLLIIEDHDEMREYLC
SLFKEDYNVIEAENGEEGVAMADKYIPKLIISDIMMPVKDGFECSREIRENKRTFHIPII
FLTAKAEDADRLKSLQIGVDDYIMKPFNPELLKEKVKALIEQRDLLRKLYAKTLMLDEEV
LESSEDVQDVFMPKMLQIIEENLSNRNFTIKVLTDKLNMSQPTLYRKVKQKTGLSIIEVI
HGVRMSKAASIIMSGRYSSLTEVAEMVGYDSMISFRKQFVAQFGVLPSKYMEEKMRK