Protein Info for BT2230 in Bacteroides thetaiotaomicron VPI-5482

Annotation: DNA polymerase III alpha subunit (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1267 PF02811: PHP" amino acids 6 to 222 (217 residues), 169.5 bits, see alignment E=2e-53 TIGR00594: DNA polymerase III, alpha subunit" amino acids 390 to 1139 (750 residues), 846.6 bits, see alignment E=1.6e-258 PF07733: DNA_pol3_alpha" amino acids 400 to 668 (269 residues), 300.2 bits, see alignment E=3.7e-93 PF17657: DNA_pol3_finger" amino acids 671 to 834 (164 residues), 192.1 bits, see alignment E=1.1e-60 PF14579: HHH_6" amino acids 907 to 996 (90 residues), 100.7 bits, see alignment 1.1e-32 PF01336: tRNA_anti-codon" amino acids 1103 to 1182 (80 residues), 32.2 bits, see alignment 2.1e-11

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 100% identity to bth:BT_2230)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A5K9 at UniProt or InterPro

Protein Sequence (1267 amino acids)

>BT2230 DNA polymerase III alpha subunit (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MQDFVHLHVHTQYSLLDGQASVARLVDKAMKNGMKGIAVTDHGNMFGIKEFTNYVNKKNS
GPKGEIKDLKKRIAGIEAGTVECEDKEAEVAACKAKIVEAENKLFKPIIGCEMYVARRTM
DLKEGKPDQSGYHLIVLAKNEKGYHNLIKLVSHAWTRGYYMRPRTDRSELEKYHEGLIVC
SACLGGEVPKRITAGQFAEAEEAIQWYKNLFGDDYYLEMQRHKATVPRANHECYPLQVNV
NKYLQEYARKYNIKLICTNDVHFVDEENAEAHDRLICLSTGKDLDDPSRMLYTKQEWMKT
REEMNELFADVPEALSNTLEILDKVEYYSIDHAPIMPTFAIPEDFGTEEGYRAKYTEKDL
FDEFTQDENGNVVLSEEEGQAKIKRLGGYEKLYRIKLEGDYLAKLAFDGAKRIYGDPLSE
EVKERLNFELYIMKTMGFPGYFLIVQDFINAARSELGVSVGPGRGSAAGSAVAYCLGITK
IDPIQYDLLFERFLNPDRISLPDIDVDFDDDGRGEVLRWVTNKYGQEKVAHIITYGTMAT
KLAIKDVARVQKLPLSESDRLAKLVPDKIPDKKLNLRNAIEYVPELQAAEASSDPLVRDT
LKYAKMLEGNVRGTGVHACGTIICRDDITDWVPVSTADDKETGEKMLVTQYEGSVIEDTG
LIKMDFLGLKTLSIIKEAVENIRLSRSLEIDVDQIDITDPATYKLYSDGRTIGTFQFESA
GMQKYLRELQPSTFEDLIAMNALYRPGPMDYIPDFIDRKHGRKPIEYDIPVMEKYLKDTY
GITVYQEQVMLLSRLLADFTRGESDALRKAMGKKLRDKLDHMKPKFIEGGRKNGHDPKVL
EKIWTDWEKFASYAFNKSHATCYSWVAYQTAYLKANYPSEYMAAVMSRSLSNITDITKLM
DECKAMGIQTLGPDVNESNLKFTVNHDGNIRFGLGAVKGVGEAAVQSIVEERNTNGPFKG
IFDFVQRVNLNACNKKNMECLALAGGFDSFPELKREQYFAVNSKGEVFLETLMRYGNRYQ
EDKRAAINSLFGGANVVDIATPEIPQGVERWGDLERLNKERDLVGIYLSAHPLDEFAIVL
DHVCNTRMADLEDKAALAGREITMGGIVTSVRRGVSKNGNPYGIAKIEDYSGSTEIPFWG
NDWVTYQGYLNEGTFLYIKARCQAKQWRQDELEVKITSMELLPDVKEELVQKITIIIPLS
VLNSGLITELATLTKEHPGNTELYFKVTDDTDSRMSVDLISRPVKLSVGRDLITYLKERP
ELGFRIN