Protein Info for BT2039 in Bacteroides thetaiotaomicron VPI-5482
Annotation: cation efflux system protein, AcrB/AcrD/AcrF family protein (NCBI ptt file)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to bth:BT_2039)Predicted SEED Role
"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q8A647 at UniProt or InterPro
Protein Sequence (1042 amino acids)
>BT2039 cation efflux system protein, AcrB/AcrD/AcrF family protein (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482) MLNKIIHYSLHNRLVVLCAAILLLIAGTYTAMHTEVDVFPDLNAPTVVIMTEANGMAAEE VEQLVTFPVETAVNGATGVRRVRSSSTNGFSVVWVEFDWGTDIYLARQIVSEKLAVVSES LPVNVGKPTLGPQSSILGEMLIVGLTADSTSMLDLRTIADWTIRPRLLSTGGVAQVAVLG GDIKEYQIQLDPERMRHYGVSMGEVMAVTQDMNLNANGGVLYEFGNEYIARGVLSTPKVE ELGKAVVKTVNNFPVTLEDIADVKIGPKAPKLGTASERGKPAVLMTVTKQPATSTLELTD KLEASLQDLQKNLPADVKVSTDIFRQSRFIESSIGNVKKSLFEGGIFVVIVLFLFLANVR TTLISLVTLPLSLLVSILTLHYMGLTINTMSLGGMAIAIGSLVDDAIVDVENVYKRLREN RQKAEAERFSTLEVVFNASKEVRMPILNSTLIIVVSFVPLFFLSGMEGRMLVPLGIAFIV ALFASTVVALTLTPVLCSYLLGSNKTNKELKESFVARWMKGIYEKALTWVLAHKRVTLGS TIVLFLIALGVFFTLGRSFLPSFNEGSFTINISSLPGISLEESNKMGHRAEELLLTIPEI QTVARKTGRAELDEHALGVNVSEIEAPFELKDRPRSELVAEVREKLGTITGANIEIGQPI SHRIDAMLSGTKANIAIKLFGDDLNKMFSLGNQIKGAISDIPGIADLNVEQQIERPQLKI QPKREMLAKFGITLPEFSEYVNVALAGKVISQVYEQGKSFDLIVKVKDDARDEMEKIRNL MVDTNDGRKVPLNYVAEVVSSMGPNTINRENVKRKIVISANVADRDLRSVVNDIQKQVDA TIQLPEGYHIEYGGQFESEQAASRVLALTSFMSIVIIFLLLYHEFRSVKESGVILLNLPL ALIGGVFALVITTGEVSIPAIIGFISLFGIATRNGMLLISHYNHLQQVEGLNVYDSVVQG SLDRLNPILMTALSSALALIPLALGGDLPGNEIQSPMAKVILGGLLTSTFLNGFIVPIVY LMMHRQRSAGANSPCGVPAEQA