Protein Info for BT1661 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 601 PF08447: PAS_3" amino acids 282 to 358 (77 residues), 32.9 bits, see alignment E=1.3e-11 PF00512: HisKA" amino acids 386 to 450 (65 residues), 76.1 bits, see alignment E=3.5e-25 PF02518: HATPase_c" amino acids 496 to 599 (104 residues), 94.8 bits, see alignment E=9.4e-31

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_1661)

Predicted SEED Role

"Two-component system sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A764 at UniProt or InterPro

Protein Sequence (601 amino acids)

>BT1661 two-component system sensor histidine kinase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MGWWEADLKTESYVCSEFISRLLGIDEDGVISFEDFNKRILREDQHHTTSYSFDKLQQSI
EEVYLLDTPHGEVWIRSKICFQETDGEGNTKIYGIAETQDGPRMASAYQALQNSERILHN
IYKNLPVGIELYNKDGYLLDLNKKELEMFHITHKEKVIGINIFENPALPEEIKLKIRDNE
EVEFTFQYDFSKIKGYYESEKTSGFINLTTRITTLYDHDRQPINYLLINVDKTENTIAYN
KIQEFKNFFELVGDYAKVGYAHFDALSRNGYALSSWYKNVGEEEGTPLPEIIGIHSHFHP
EDRAVMLDFLAKVVKGESTKLCRDVRIRRADGSYTWTRVNVLVRNYRPQDNVIEMLCINF
DITQLKETEQMLIKAKEKAEEADRLKSAFLANMSHEIRTPLNAIVGFSSMLEEAEDQEEK
HQYITIIEDNNKLLLQLISDILDLSKIEAGTFDIIPERVNAKQLCNDLFQAMQMKTSPQV
ELRLKDNLPELTFTSDKNRLYQVLLNFVTNALKFTSEGNITIDYQIDGNEVKFSVQDTGM
GIEPEKQEAIFTRFVKLNSFIPGTGLGLPICQSIVTQLGGKIGVESEPGRGACFWFTHPI
N