Protein Info for BT1651 in Bacteroides thetaiotaomicron VPI-5482
Annotation: pyrophosphorylase (NCBI ptt file)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to bth:BT_1651)Predicted SEED Role
"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) / short chain dehydrogenase" in subsystem Isoprenoid Biosynthesis or Teichoic and lipoteichoic acids biosynthesis or polyprenyl synthesis (EC 2.7.7.60)
MetaCyc Pathways
- methylerythritol phosphate pathway II (9/9 steps found)
- superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (9/12 steps found)
- taxadiene biosynthesis (engineered) (9/13 steps found)
- methylerythritol phosphate pathway I (6/9 steps found)
- isoprene biosynthesis I (6/10 steps found)
- superpathway of ergosterol biosynthesis II (8/26 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Terpenoid biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.7.7.60
Use Curated BLAST to search for 2.7.7.60
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q8A774 at UniProt or InterPro
Protein Sequence (453 amino acids)
>BT1651 pyrophosphorylase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482) MRNIAVILAGGSGQRLGENIPKQFLKIAGKKVIEHTITVFQNHSLIDEIVVVVHPDYIRD VEDISLRNSFNKLKKILLGGKERYHSSLAAINAYDEEVNLLFHDSVRPLVNERIINDCIR ALLTYNAVDVAIPTTDTIIQVDDNNEIVKIPSRILLRNGQTPQAFKRSVIKAAYEKALLD PLFKTTDDCGVVLKYLPDESIYVVNGEQFNMKLTYKEDIFLLDKLFQLRSIRNQPTLLEK SEMEELQGKVVVVFGGTYGIGQDICEICREYKTSLYVYSRSTGVDVSNSQSVRRVLSEIF DKEGRIDWIVNTAGILDKQPLANMSYEAVHQSIDVNYLGNIIVAKESFFYLKESKGSLLF FTSSSYTRGRALYSLYSSSKAAIVNFVQALSEEWFEYGIRVNCINPERTKTPMRIQNFGN EPEDTLLEPKVVAIVSVNTLLSEMTGEVVDVKR