Protein Info for BT1627 in Bacteroides thetaiotaomicron VPI-5482

Annotation: beta-hexosaminidase precursor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 776 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 30 to 159 (130 residues), 77.3 bits, see alignment E=4.5e-25 PF00728: Glyco_hydro_20" amino acids 163 to 517 (355 residues), 406.5 bits, see alignment E=2.9e-125 PF13290: CHB_HEX_C_1" amino acids 561 to 617 (57 residues), 55.4 bits, see alignment 1.2e-18 PF13287: Fn3_assoc" amino acids 564 to 620 (57 residues), 58.9 bits, see alignment 1.1e-19 PF00754: F5_F8_type_C" amino acids 648 to 751 (104 residues), 29.7 bits, see alignment E=1.6e-10

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to bth:BT_1627)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A798 at UniProt or InterPro

Protein Sequence (776 amino acids)

>BT1627 beta-hexosaminidase precursor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MTRAILILLIGFLSSIVAGCSDTNLTHDIPLVPRPAQIVPGSGNYLFSGKTVFAVENEEQ
AEVARSFIALFTRAAGFTPKLTVGDAEKGNVRFQTDATLKSEAYTLQVSPKEIIIEASDA
KGFFYALQTIRQLLPASIEKEEVSDKKVKWSIPAVSIQDEPRFGYRALLLDASRFFIPKE
NVLRIIDCMAMLKINTLHFHLTDDNGWRVEIKKYPRLTEVGAWRVDRTDLPFPARRNPEP
GEPTPVGGFYTQEEIKEMVAYAAERQIEVVPEIDMPAHSNSALAAYPHLACPVVKEYIGV
LPGLGGRNSEIIYCAGNDSVYAFLQDVMDEILELFPSRYIHIGGDEARKTYWEKCPLCQA
RMKKEKIANEEDLQGYFMNRMSEYVRSKGREVIGWDELTNSSFLPDDAIILGWQGYGQAA
LKAAEKGHRFIMTPARIMYLIRYQGPQWFEPLTYFGNNTLKDVYDYEPVQKDWKPEYADL
LMGVQACMWTEFCNKPEDVDYLVFPRLAALAEVAWTQPEKKDWTSFLEGMDSFNEHLAAK
GIVYARSMYNIQHTVRPEDGALKVKLECVRPDVEIRYTMDGSEPTAASPLYEQPLLVKEA
QTVNAATFADGQQMGKTLTLPVHWNKATAKPLLGNKVNEAVLNNGVRGSLKQTDFEWCSW
GSSDRISFTVDLLQKEKMNTLTIGCITNYGMGVHKPKSIRVAVSDDNATYRDINELEYTP
EEIFREGTFIEDLSIDMRGTVARYVRVTTEGAGECPANHVRPGQESRVCFDELIIE