Protein Info for BT1273 in Bacteroides thetaiotaomicron VPI-5482
Annotation: L-fucose isomerase (NCBI ptt file)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to FUCI_BACTN: L-fucose isomerase (fucI) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
KEGG orthology group: K01818, L-fucose isomerase [EC: 5.3.1.25] (inferred from 100% identity to bth:BT_1273)MetaCyc: 63% identical to L-fucose isomerase (Escherichia coli K-12 substr. MG1655)
Arabinose isomerase. [EC: 5.3.1.3]; L-fucose isomerase. [EC: 5.3.1.3, 5.3.1.25]
Predicted SEED Role
"L-fucose isomerase (EC 5.3.1.25)" in subsystem L-fucose utilization (EC 5.3.1.25)
MetaCyc Pathways
- superpathway of fucose and rhamnose degradation (10/12 steps found)
- L-fucose degradation I (4/4 steps found)
- D-arabinose degradation I (2/2 steps found)
- D-arabinose degradation II (3/4 steps found)
- superpathway of pentose and pentitol degradation (12/42 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 5.3.1.25 or 5.3.1.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q9RQ13 at UniProt or InterPro
Protein Sequence (591 amino acids)
>BT1273 L-fucose isomerase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482) MKKYPKIGIRPTIDGRQGGVRESLEEKTMNLAKAVAELISNNLKNGDGSPVECIIADNTI GRVAESAACAEKFEREGVGSTITVTSCWCYGAETMDMNPHYPKAVWGFNGTERPGAVYLA AVLAGHAQKGLPAFGIYGRDVQDLDDNTIPEDVAEKILRFARAAQAVATMRGKSYLSMGS VSMGIAGSIVNPDFFQEYLGMRNESIDLTEIIRRMEEGIYDHEEYAKAMAWTEKYCKVNE GEDFKNRPEKRKKREQKDADWEFVVKMMIIMRDLMTGNPKLKEMGFKEEALGHNAIAAGF QGQRQWTDFYPNGDYPEALLNTSFDWNGIREAFVVATENDACNGVAMLFGHLLTNRAQIF SDVRTYWSPEAVKRVTGKELTGLAANGIIHLINSGATTLDGSGQSLDAEGNPVMKEPWNL TDADVENCLKATTWYPADRDYFRGGGFSSNFLSKGGMPVTMMRLNLIKGLGPVLQIAEGW TVEIDPEIHQKLNMRTDPTWPTTWFVPRLCDKSAFKDVYSVMNNWGANHGAISYGHIGQD LITLASMLRIPVCMHNVDENEIFRPTAWNAFGMDKEGADYRACTTYGPIYK