Protein Info for BT0958 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1329 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details transmembrane" amino acids 765 to 789 (25 residues), see Phobius details PF07494: Reg_prop" amino acids 28 to 50 (23 residues), 16.3 bits, see alignment (E = 3e-06) amino acids 342 to 363 (22 residues), 18.9 bits, see alignment (E = 4.2e-07) PF07495: Y_Y_Y" amino acids 695 to 760 (66 residues), 47.5 bits, see alignment 4.8e-16 PF00512: HisKA" amino acids 801 to 864 (64 residues), 30.6 bits, see alignment 1e-10 PF02518: HATPase_c" amino acids 913 to 1022 (110 residues), 84.7 bits, see alignment E=2.2e-27 PF00072: Response_reg" amino acids 1065 to 1175 (111 residues), 80.8 bits, see alignment E=2.9e-26 PF12833: HTH_18" amino acids 1240 to 1313 (74 residues), 66.2 bits, see alignment 9.3e-22 PF00165: HTH_AraC" amino acids 1279 to 1311 (33 residues), 30.4 bits, see alignment (E = 1.2e-10)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_0958)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A959 at UniProt or InterPro

Protein Sequence (1329 amino acids)

>BT0958 two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MRNIILFLLLLPLMAYGQTYKHIGVEDGLSNRRIYNIQKDHQGYMWFLTNEGMDRYNGKD
IKHYKLIEENKQLSSEIHLGWLYADKEGGIWVIGKKGRIFQYEEKYDRFTMVYKSPKVTD
AISYGYLDRNNNLWLCGKDSILLYNTKTTQVMRLPNLLEDNITVVEQADDTHFFIATEMG
VRYTQFENEALKVIPLDMLDHVYTQINSLYFHPQLHRLFVGTFSDGTFAYDMSAHQIIKS
DTKLGDVSITHIRPLNQKELLVATEGMGVHKIDVNTCNTSPFIVANYESYNEMNGNNITD
IYIDEEKRIWLANYPAGITVVDFRYKNYRWIKHSIGNKQSIVNDQVHAVIEDSEGDLWFG
TSNGISFQDSKTGQWHSFLSSYDKQLKDKNHIFITLCEVSPGVIWAGGYTSGIYKINKKT
LSVEYFSPFLLSSVNIRPDKYIRDMIKDSKGYIWSGGYYNLKCIDPRKNTVRLYPGVNTV
TAIEEKDTNFMWVGTATGLFLLNRNSGEYQYILMPVESTYINTLYQANDGLLYIGTNGSG
VLIYDPGNMSFEHYYADNSALVSNSIYTILPEMNGQIMMSTENGITSFSIEKRSFHNWSR
EQGMMSACFNATSGALRKNNNFVFGSVDGAVEFPAGIKLPDYEYSKMIFSDFHISYQPIY
PGEKDSPLEKDIDKTDVLRLKYGENTFSFRVSSINYDFPSHSVYYWRLEGSSYNEWVQLS
GNSLIRFTNLSPGKYKLYVRAISKEEPSIVFEERQVGIIISQPVWLNGWAIFIYMLLIVF
VFSIAFRIMILKKQKKISDEKTHFFINTAHDIRTPLTLIKAPLEEFVEEETLTEIGSQRI
NTALRNVNALLRLSTNLINFERADVYSSELRISEYELNTYMNEICNSFRSYANIKHIDFT
YKSDFNYLNVWFDKDKMDSILKNLISNALKYTPENGIVSVSISETKDSWKLEVKDTGIGI
PANEQNKLLKMHFRGTNGINAKITGSGIGLKLVDKLVHLHSGKINIESVEQQGTTITVVF
PKGNKHFRHSNLIDPEKTGRQEAVLDAPVISEAAEKTNDENLQRILIVEDNDELRAYLVN
SLSPMYNVQACGNGKEALIIVKEFWPELILSDIMMPEMRGDELCSTIKNDIETSHIPVLL
LTALGEEQNILDGLDIGADEYIVKPFSIRILKASIANLLANRALLRSKYANLEIDIEVKT
PLAKCTNSLDWQFLSAVKKTIEDNINNPAFSVEVLNDLHNMSRTRFYYKLKAITGLSPQE
LIKTTRLKRATQLLKEGEYNITEISEMCGFSESKYFREVFKKEYKMSPSQYAKKYSISSS
GIIEDDSDE