Protein Info for BT_0823 in Bacteroides thetaiotaomicron VPI-5482
Annotation: glucuronate isomerase (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to UXAC_BACTN: Uronate isomerase (uxaC) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
KEGG orthology group: K01812, glucuronate isomerase [EC: 5.3.1.12] (inferred from 100% identity to bth:BT_0823)MetaCyc: 57% identical to D-glucoronate/D-galacturonate isomerase (Escherichia coli K-12 substr. MG1655)
Glucuronate isomerase. [EC: 5.3.1.12]; 5.3.1.12 [EC: 5.3.1.12]
Predicted SEED Role
"Uronate isomerase (EC 5.3.1.12)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 5.3.1.12)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (9/10 steps found)
- D-galacturonate degradation I (5/5 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- β-D-glucuronide and D-glucuronate degradation (2/3 steps found)
- pectin degradation II (3/5 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (15/31 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 5.3.1.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q8A9J2 at UniProt or InterPro
Protein Sequence (468 amino acids)
>BT_0823 glucuronate isomerase (RefSeq) (Bacteroides thetaiotaomicron VPI-5482) MKNFMDENFLLQTETAQKLYHEHAAKMPIIDYHCHLIPQMVADDYKFKSLTEIWLGGDHY KWRAMRTNGVDERYCTGKDTTDWEKFEKWAETVPYTFRNPLYHWTHLELKTAFGIDKILS PKTAREIYDECNEKLAQPEYSARGMMRRYHVEVVCTTDDPIDSLEYHIQTRESGFEIKML PTWRPDKAMAVEVPADFRAYVEKLSAVSGVTISNFDDMIAALRKRHDFFAEQGCRLSDHG IEEFYAEDYTDAEIKAIFNKVYGGAELTKEEILKFKSAMLVIFGEMDWEKGWTQQFHYGA IRNNNTKMFKLLGPDTGFDSIGEFTTAKAMSKFLDRLNVNGKLTKTILYNLNPCANEVIA TMLGNFQDGSIAGKIQFGSGWWFLDQKDGMEKQMNALSVLGLLSRFVGMLTDSRSFLSYP RHEYFRRTLCNLVGRDVENGEIPVSEMDRVNQMIEDISYNNAKNFFKF