Protein Info for BT0749 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative two-component system sensor histidine kinase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1415 transmembrane" amino acids 135 to 149 (15 residues), see Phobius details amino acids 412 to 433 (22 residues), see Phobius details amino acids 796 to 814 (19 residues), see Phobius details amino acids 973 to 992 (20 residues), see Phobius details PF17139: DUF5112" amino acids 10 to 273 (264 residues), 331.4 bits, see alignment E=6.5e-103 PF17140: DUF5113" amino acids 275 to 436 (162 residues), 202 bits, see alignment E=8.5e-64 amino acids 838 to 995 (158 residues), 186.7 bits, see alignment E=4.3e-59 PF02518: HATPase_c" amino acids 674 to 794 (121 residues), 60.9 bits, see alignment E=2.4e-20 amino acids 1299 to 1414 (116 residues), 29 bits, see alignment E=1.8e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_0749)

Predicted SEED Role

"putative two-component system sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A9R6 at UniProt or InterPro

Protein Sequence (1415 amino acids)

>BT0749 putative two-component system sensor histidine kinase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MVPTKEVRLIDSLNGKAYAYRYRNLDSSYKYAYKAYRQVNLYKSGKAEASNNLGFCAFMN
MDFDRAEAYHKEVYKLTKNELELLIADIGLMKICQRTALNKEFYDYRNSALRRMKRIREE
SDLFADRHEALRLDYAFTEFFLVSSIYYYYLQQRQEAITSIDNIQEDEALSDTNQLLYYH
YLKGSASLVAANTPEERKLREFDELYFTWRTAVKSKHPYFEGNGMQGLANLMASPSNFEF
FKTRRTHALDQFDFPVDSLFPLRLAQLALEKFREYNDLYQIAGAYVSIGKYLNAHGRYQE
ALDTLSKALNCVNHHHMLYYHNEVDTLDKLYTFAEGDTTYTGVPWIGQEKVKTVPEWISR
IREQLSVSYAGLGMKDASDYNRNIYLDILNFTRQDKELESRYLSLEAGSRQMTVVLFLVI
VGLVLVIILWWFFNKRSKIRNQVDVERLQRILSLCRDITSSIPMNVPLIQQGIDQLFGKG
RLTLEIPEEGKAALVPSSHRLNRDEKALVHVVEPYIVWAAENEQMVATLSDERNQLEKQR
YIYEQHIAGNKRQNLIKKACMAIVNGINPYIDRILNEVHKLTEKGYIDDTKIKKEKYQYI
DELVTTINEYNDILALWIKMKQGTLSLNIETFSLNELFDLLGKGRRAFEMKKQKLEIEPT
TLMVKADRALTLFMINTLAENARKYTPEGGTVKVYAHATDAYVEISVEDNGRGLSAEDIA
HIIGEKVYDSRAIGMKDAADPEELKENKGSGFGLMNCKGIIEKYKKTNELFRVCVFDIES
EPGKGSRFYFRLPSGVRKVIGVLLCLLLPLGMASCLHEPLPSILQDSDSIAITTDSTYED
LLDAASDYANAAYFANVDENYEIALQYIDSAMMSLNEHYKKYTRTPKPHRYMKLVGKGTP
AELFWWNELFDSDYHVILDIRNEAAVAFLALKQIDAYSYNNSAFTDLYKVQGEDQTLEGY
CRQLERSNTNKTVGIILCFVLLIVSLIGYYLLYMRKMLQNRLNLEQVLEINQKVFAASLV
RPQTQENEEALQREENTLKEIPQRIVNEAFGSVNELLTISLMGIAVYNETTHRLEYASCP
GQEMPEMVQQCFETGEYLSEQNLQAIPLMVEAGGEHQCVGVLYLERREGTQQETDHLLFE
LVARYVSIVVFNAVVKLATQYRDIESAHEETRRASWEDSMLHVQNMVLDNCLSTIKHETI
YYPNKIKQIIGRLNTQNLPEKDEREAVETITELIEYYKGIFTILSSCAARQLEEVTFRRN
TIPVQELFDAAGKYFRKVTKNRTEKVELIIEPMDAKVIGDVNQLRFLFENLIDEALAVRE
EGVIRLQARKDNEYIRFLFTDTRREKSVTELNQLFYPNLARMTSGEKGELRGTEYLICKQ
IIRDHDEFAGRRGCRINAEPAEGGGFTVYFTIPRR