Protein Info for BT0634 in Bacteroides thetaiotaomicron VPI-5482

Annotation: Na+/H+ antiporter 1 (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 65 to 85 (21 residues), see Phobius details amino acids 103 to 123 (21 residues), see Phobius details amino acids 134 to 153 (20 residues), see Phobius details amino acids 162 to 183 (22 residues), see Phobius details amino acids 189 to 205 (17 residues), see Phobius details amino acids 214 to 247 (34 residues), see Phobius details amino acids 265 to 276 (12 residues), see Phobius details amino acids 309 to 328 (20 residues), see Phobius details amino acids 336 to 360 (25 residues), see Phobius details amino acids 379 to 400 (22 residues), see Phobius details amino acids 412 to 433 (22 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 9 to 429 (421 residues), 439.8 bits, see alignment E=3.8e-136 TIGR00773: Na+/H+ antiporter NhaA" amino acids 10 to 429 (420 residues), 372.5 bits, see alignment E=1.1e-115

Best Hits

Swiss-Prot: 100% identical to NHAA_BACTN: Na(+)/H(+) antiporter NhaA (nhaA) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 100% identity to bth:BT_0634)

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8AA31 at UniProt or InterPro

Protein Sequence (439 amino acids)

>BT0634 Na+/H+ antiporter 1 (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MTILRTMRNFSSMNIAASILLFVAAIAAAIIANSPVAPVYQEFLLHELHLQIGNFNLLSH
GGENLRMIEFINDGLMTIFFLLVGLEIKRELLVGELSSFRKAALPFIAACGGMLFPVIVY
MSICPPGSAGSQGLAIPMATDIAFSLGVLSLLGSRVPLSLKIFLTAFAVVDDIGGILVIA
LFYSSHVSYGYILIAALLYVLLYFIGKRGTTNKIFFLVIGVVIWYLFLQSGIHSTISGVI
LAFVIPAKPRLDVGKYIEHIRHTIAGFPVVESGSIVLTNEQIAKLKEVESASDRVISPLQ
SLEDNLHGAVNYLILPLFAFVNAGVVFSGGGELVGSVGMAVAAGLLFGKFAGIYFFTWLA
IKIKLTPMPPGMTWKNLSGIALLGGIGFTVSLFIANLSFGANYPVLLNQAKFGVLSGTIL
SGLLGYIVLRIVLPVRKRK