Protein Info for BT0578 in Bacteroides thetaiotaomicron VPI-5482

Annotation: excinuclease ABC subunit A (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 946 TIGR00630: excinuclease ABC subunit A" amino acids 12 to 929 (918 residues), 1349.1 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 139 to 244 (106 residues), 112.6 bits, see alignment E=2.7e-36 PF17755: UvrA_DNA-bind" amino acids 296 to 404 (109 residues), 90.3 bits, see alignment E=3e-29

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 100% identity to bth:BT_0578)

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8AA87 at UniProt or InterPro

Protein Sequence (946 amino acids)

>BT0578 excinuclease ABC subunit A (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKDMNMQETEYINVYGARVHNLKDIDAEIPRNSLTVITGLSGSGKSSLAFDTIFAEGQRR
YIETFSAYARNFLGNLERPDVDKITGLSPVISIEQKTTNKNPRSTVGTTTEIYDYLRLLY
ARAGIAYSYLSGEEMVKYTEEQILDLILKDYKGKKIYLLAPLVRSRKGHYKELFEQVRKK
GYLYVRIDGELREVTHGMKLDRYKNHDIEVVIDKLIVAEKDDKRLKQSVATAMRQGDGLL
MILDAQTESVRHYSKRLMCPVTGLSYREPAPHNFSFNSPQGACPKCKGLGVVNQIDVDKV
IPDRELSIYEGAIAPLGKYKNAMIFWQIGALLEKYEATLKTPVKELSDDAVEEILYGSDD
RIKIKSSLIGTSSDYFVTYEGVVKYIQMLQEKDASATAQKWAEQFARTTVCPECKGARLN
KEALHFRIHDKNINDLANMDINELYDWLMNVDQFLSDKQKKIAAEILKEIRTRLKFLLDV
GLDYLALNRSSVSLSGGESQRIRLATQIGSQLVNVLYILDEPSIGLHQRDNLRLIRSLKE
LRDMGNSVIVVEHDKDMMLAADYVIDMGPKAGRLGGEVVFSGTPSEMLQTETMTSQYLNG
EMKIEVPAKRRKGNGKSIWLKGAKGNNLKNVDVEFPLGKLICVTGVSGSGKSTLINETLQ
PILSQKFYRSLQDPLEYDSIEGLENIDKVVDVDQSPIGRTPRSNPATYTGVFSDIRNLFV
SLPEAKIRGYKPGRFSFNVSGGRCEACTGNGYKTIEMNFLPDVYVPCEVCHGKRYNRETL
EVRFKGKSIADVLDMTINRAVEFFENVPQILNKIKVLQDVGLGYIKLGQSSTTLSGGESQ
RVKLATELSKRDTGKTLYILDEPTTGLHFEDIRVLMGVLNKLVDKGNTVIVIEHNLDVIK
MADYIIDMGPEGGKGGGVLLSYGTPEEVAKSQKGYTPKFLREELGL