Protein Info for BT0356 in Bacteroides thetaiotaomicron VPI-5482

Annotation: aldose 1-epimerase precursor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01263: Aldose_epim
  • amino acids 47 to 373 (327 residues), 303.5 bits, E=9.2e-95

Best Hits

KEGG orthology group: K01785, aldose 1-epimerase [EC: 5.1.3.3] (inferred from 100% identity to bth:BT_0356)

Predicted SEED Role

"Aldose 1-epimerase (EC 5.1.3.3)" in subsystem Lactose and Galactose Uptake and Utilization or Maltose and Maltodextrin Utilization (EC 5.1.3.3)

MetaCyc Pathways

• D-galactose degradation I (Leloir pathway) (4/5 steps found)
• trehalose degradation VI (periplasmic) (1/2 steps found)

KEGG Metabolic Maps

• Glycolysis / Gluconeogenesis

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.3

Use Curated BLAST to search for 5.1.3.3

Sequence Analysis Tools

See Q8AAV6 at UniProt or InterPro

Protein Sequence (379 amino acids)

>BT0356 aldose 1-epimerase precursor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKKHFLIAGIAALMLAACNNKPASELTLSGLDPAKFQTEVNNAQTALYTLKNKAGMEVCI
TNFGGRIVSIMVPDKNGKMQDVVLGFDSIADYINVPSDFGASIGRYANRINQGRFVLDGD
TIQLPQNNFGHCLHGGPKGWQYQVYEANLIDPTTLELTLISPDGDANFPGNVTAKVTYQL
TDDNAIDIKYSATTDKKTIINMTNHSYFNLAGDPSKTSTDNIMYVNADYYTPVDSTFMTT
GEIAPVKDTPMDFTTPKAVGKDINNYDFVQLKNGNGYDHNWVLNTKGDISQVAARLTSPE
TGITLEVYTNEPGIQVYTGNFLDGTVSGKKGIVYNQRASVCLETQHYPDSPNKADWPSVV
LEPGQTYNSECIFKFSTEK