Protein Info for BT0252 in Bacteroides thetaiotaomicron VPI-5482

Annotation: transcription-repair coupling factor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1127 PF17757: UvrB_inter" amino acids 144 to 229 (86 residues), 74.9 bits, see alignment 1.3e-24 TIGR00580: transcription-repair coupling factor" amino acids 238 to 1048 (811 residues), 887.8 bits, see alignment E=5.5e-271 PF02559: CarD_TRCF_RID" amino acids 435 to 490 (56 residues), 59 bits, see alignment 1.2e-19 PF00270: DEAD" amino acids 560 to 721 (162 residues), 80.6 bits, see alignment E=3.5e-26 PF04851: ResIII" amino acids 560 to 716 (157 residues), 28.5 bits, see alignment E=4.1e-10 PF00271: Helicase_C" amino acids 758 to 864 (107 residues), 62.4 bits, see alignment E=1.4e-20 PF03461: TRCF" amino acids 977 to 1068 (92 residues), 75.4 bits, see alignment E=1.1e-24

Best Hits

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 100% identity to bth:BT_0252)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8AB59 at UniProt or InterPro

Protein Sequence (1127 amino acids)

>BT0252 transcription-repair coupling factor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MTITELQQQYAAHPNTAVMERLLKDASVQTIFCGGLCASSASLFSSVLVKQDVCPFVFVL
GDLEEAGYFYHDLTQVLGTEKVFFFPSSFRRSIKYGQKDAANEILRTEVLSRLQKGEEGL
CIVTYPDALAEKVVSRKELSDKTLKLNVGEKLDTTFITDVLHSYGFEYVDYVYEPGQYAV
RGSIIDVFSFASEYPYRIDFFGDEVESIRTFEVESQLSRERKEGVAIVPDLAVTGDVTTS
FLDFIPKETVLAMRDFLWLRERIQVVHDEALTPQAIAVQEAEENGGITLEGKLIDGSEFT
VRALDFRRMEFGNKPTGTPDAKISFHTSVQPIFHKNFDLVAGSFKDYLEQGYSLYICSDS
TKQTDRIRAIFEDRGDKIQFTPVVRTIHEGFVDHTLHLCIFTDHQLFDRFHKYNLKSDKA
RSGKVALSLKELNQFTPGDYVVHTDHGIGRFSGLVRIPNGDTTQEVLKLVFQNEDVVFVS
IHSLHKVSKYKGKDGEAPRLNKLGTGAWEKLKDRTKAKIKDIARDLIKLYSQRRQEKGFS
YSPDSFLQRELEASFIYEDTPDQSKATMEVKADMESDRPMDRLVCGDVGFGKTEVAIRAA
FKAVADNKQVAVLVPTTVLAYQHFQTFRERLKGLPCRVEYLSRARTAAQSKAVLKGLKEG
EVSILIGTHRILGKDVQFKDLGLLIIDEEQKFGVSVKEKLRQLKVNVDTLTMTATPIPRT
LQFSLMGARDLSVISTPPPNRYPIQTEVHTFNEEVITDAINFEMSRNGQVFFVNNRIANL
PELKVMIERHIPDCRVAIGHGQMEPTQLEQIIFDFVNYDYDVLLATTIIESGIDIPNANT
IIINQAQNFGLSDLHQMRGRVGRSNKKAFCYLLAPPLSSLTAEGKRRLQAIENFSDLGSG
IHIAMQDLDIRGAGNLLGAEQSGFIADLGYETYQKILAEAVHELRNDEFAELYADEIKGE
GQISGEEFVDECQIESDLELLLPATYVTGSSERMLLYRELDGLTLDKDVDAFRFRLEDRF
GPVPPETQELLRIVPLRRLAARLGVEKVFLKGGRMTLFFVSNADSPFYQSQAFGKMIDYM
MKYTRRCDLREQNGRRSMLIKDVTNVETAVSVLQEIVALPVKELDDH