Protein Info for DVU0628 in Desulfovibrio vulgaris Hildenborough JW710
Name: buk
Annotation: butyrate kinase (TIGR)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to BUK_DESAG: Probable butyrate kinase (buk) from Desulfovibrio alaskensis (strain G20)
KEGG orthology group: K00929, butyrate kinase [EC: 2.7.2.7] (inferred from 100% identity to dvu:DVU0628)Predicted SEED Role
"Butyrate kinase (EC 2.7.2.7)" in subsystem Acetyl-CoA fermentation to Butyrate or Isoleucine degradation or Valine degradation (EC 2.7.2.7)
MetaCyc Pathways
- L-threonine degradation I (5/6 steps found)
- superpathway of L-threonine metabolism (13/18 steps found)
- (S)-propane-1,2-diol degradation (3/5 steps found)
- superpathway of Clostridium acetobutylicum acidogenic fermentation (5/9 steps found)
- pyruvate fermentation to butanoate (3/7 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
- L-glutamate degradation VII (to butanoate) (4/12 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.2.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q72EF0 at UniProt or InterPro
Protein Sequence (372 amino acids)
>DVU0628 butyrate kinase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710) MSASQRHDRGAERILVINPGSTTTKVALFEGEVPLFDETVEHGKESLRAFPAVTDQFAFR LRAVKDVLEHHGVLDTPLDAVAGRGGLLAPMQGGTWRVGPAMLATLAEARHGEHPCNLGA ALARHFADLHGVEAYIVDPVVTDEMDDVARYTGLPQIRRRSVFHALSHRAAARVAASRCG VAYEEGRFLVAHMGGGVSVAAHRCGRIVDVVNALDGDGPITAERTGRLPVLPVLDLIERG LQTFESMRRIVLREGGLWAHCGTNDLREVERRMETGDAAAAAIFDALAYTIAKELASLAP AVLGTARGGVTTVTAVVLTGGMARSVRLTSRLEAHLGWLGPMVVLPDVEEMRALTQGVLR VLRGEEVAKEYV