Protein Info for DVU0449 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: sensor/response regulator (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1513 PF01339: CheB_methylest" amino acids 31 to 205 (175 residues), 173.7 bits, see alignment E=1.8e-54 PF03705: CheR_N" amino acids 236 to 287 (52 residues), 48.4 bits, see alignment (E = 3.6e-16) PF01739: CheR" amino acids 301 to 479 (179 residues), 171.3 bits, see alignment E=1e-53 PF13596: PAS_10" amino acids 749 to 852 (104 residues), 58.4 bits, see alignment 5.7e-19 TIGR00229: PAS domain S-box protein" amino acids 995 to 1112 (118 residues), 41.5 bits, see alignment 6.6e-15 PF00989: PAS" amino acids 996 to 1106 (111 residues), 23.2 bits, see alignment 3.4e-08 PF08447: PAS_3" amino acids 1021 to 1102 (82 residues), 41 bits, see alignment 1.1e-13 PF00512: HisKA" amino acids 1130 to 1194 (65 residues), 78.3 bits, see alignment (E = 2.2e-25) PF02518: HATPase_c" amino acids 1242 to 1355 (114 residues), 91.9 bits, see alignment 2.2e-29 PF00072: Response_reg" amino acids 1381 to 1494 (114 residues), 84.6 bits, see alignment 3.4e-27

Best Hits

KEGG orthology group: K13924, two-component system, chemotaxis family, CheB/CheR fusion protein [EC: 2.1.1.80 3.1.1.61] (inferred from 99% identity to dvl:Dvul_2487)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80, 3.1.1.61

Use Curated BLAST to search for 2.1.1.80 or 3.1.1.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72EW9 at UniProt or InterPro

Protein Sequence (1513 amino acids)

>DVU0449 sensor/response regulator (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPRQVDSHRAAKGRAGHHPTTHDAVHLPLVVGIGASAGGLEALEGLFRHMPTTTGAAFVV
IQHLSPDFPSFMDELLARQTVMTIVVVQDGMCPAPDHIYLLPPGKEMEITLDGFILRDKS
SYDNRPSMPINTFFASLAAWYGENAAGVVLSGTGTDGASGLEAISAAGGLVLVQLPESAA
FDGMPKAAAAACRAAVLATPDEMPDILAAFISGSPLPFEHPGLPADPASGGPAPDALQTI
FTLLQRHGGLDFRDYKPATIARRIMRRIRLEQHADIEGYARHLRDDPQAVQTLFRDLLIG
VTTFFRDETAFDTLAATVIPELFRKQGDRGEIRLWVAGCASGEEAYSLGMLLLEAAPQFD
FTGRISIFATDVHRHSLDRASAGVYTKDSLQALSPRRLQRFFIPEGDETYRVAPELRSLV
LFTQHNILADPPFTRVDLVSCRNLLIYFGVDAQERAIARLHMALRPGGVLFMGASETTGR
LHPIFEPLDPRLRIFTKRPDTLGMTATHLVHPAVIDAHRLATSSPQPSERQLLRDYDALL
QRFAPDGMLVDDRFAVLHFFGNGASYLTQHTGRTDRPITDMVEGDLRLALSSALQRASTT
GETARFKSIRVPGNGGDRLVDVEVMPIGNKPSDGKHYHVALQSSHPVLIRPLVEPAATGH
GTGLLASRVAELEAELAETRSSLRDSIEQVHVTNEELQATNEELLSANEELQATNEELHS
INEELYTVNAEFERKNDQLRILGEDYAQLFDTIPIAIASLDESLRVRRFNAGMSAIFHLQ
PHDVGRPLQQIASCLAEPDNLFKSLALGLSEGGTHDSEARLTDGRWCQQRIHAVRDETGA
TEHMLLTFMDITHVKHAEAMRQEARSLDEVSRNVPGVVFKLCAPHDGNIRVEYVGGGTVE
LCGLSQEEIKADPHALVALFGPDVVPHILAGISATDGEGTPVDVEIPLHCTGGTKWVHVQ
ATSTPARGGGTEWYGVAVDATERRYDATRMHNAADRYLRILDHAPMLIWRSDTTGACDWF
NTTWLDFTGRTMEQEYGYGWAGGVHPDDYDRCVSIYQKAFALQQAFEMNYRLKRHDGQFR
WLVDCGKPLPDLDGTFSGFIGYCYDITDAVNALESMCEASKRAEEANRTKSEFLANVSHE
LRTPLNGALGMLQLLELSSLSPEQRQYVTTAIRSGQNLVRLLSDILDLSRIEAGKLVIEA
IPCDIRELVDEVFSTFSLDATGKGITLETTIAPGTPTYVRTDPLRLRQTLFNLVGNAVKF
TEKGGVRVEFSTASMRGDAIVLFCTVRDTGPGIPEDRIESIFQPFTQLDGSYTRRHSGLG
LGLGIVCRLMELFGGSIEVESAPDMGTAMHFAIPVGKTRRPQGRKVKETEDEGDRHALYL
LVAEDDAINRLTLTRMLEQLGHRAHAVEDGSQALQALAEQHFDAVFLDIQMPVLDGMATL
QAIRTGQVAGLPPTIPVVAVTAHAMQGDRERFMAKGADAYVQKPYDFTALEKALATLGRR
VRPEGRTREDYSL