Protein Info for DVU0415 in Desulfovibrio vulgaris Hildenborough JW710

Name: pepA
Annotation: cytosol aminopeptidase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 PF02789: Peptidase_M17_N" amino acids 19 to 148 (130 residues), 84.5 bits, see alignment E=6.1e-28 PF00883: Peptidase_M17" amino acids 189 to 496 (308 residues), 402.3 bits, see alignment E=1.5e-124

Best Hits

Swiss-Prot: 100% identical to AMPA_DESVH: Probable cytosol aminopeptidase (pepA) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 100% identity to dvu:DVU0415)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72F03 at UniProt or InterPro

Protein Sequence (507 amino acids)

>DVU0415 cytosol aminopeptidase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MDIRFQAGGHAAWRAGAVMVFVFKDEPLAEVDSQLVEAAPWLTIAPAGNDFRAAKDEVAV
LHGPPAFDIPRVVAVGLGKREDCTLERIRLAAAAGIRRCRDLRVENVGVVAAQLGRMAPT
EHDALRVAEEVVCGALLGLYRYDRFRTVKDDERAEDPRWLALLCEGKNVPDDLHGAARKG
EAVALGMGVARDLVNGPANIVTPAFLASEAEALGRKHGFRVEVLGRDELSSMGMGAFASV
FRGAEEEARLIVIEHAPAGTEEQQPLVFVGKGVTFDTGGISLKPAAKMHEMKGDMAGAAA
ILGLFAALGERDLPRRVVGVLPCTENMPDGRATRPGDVVTTLSGKTVEILNTDAEGRLLL
CDALTYAQRRWQPEALVDLATLTGACVVALGTEVAGLFCDDAALADAIASRGETVGDLFW
PLPLWKSYAENLKSDVADLANVGPREGGAVNAALFLRQFIDDGVRWAHLDIAGPAFTAKK
SALCPGGGTGFAVRTLFELVSEGIPAA