Protein Info for DVU0373 in Desulfovibrio vulgaris Hildenborough JW710
Annotation: CoA-binding domain protein (TIGR)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to dvu:DVU0373)Predicted SEED Role
"Acetyl-CoA synthetase (ADP-forming) alpha chain (EC 6.2.1.13)" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 6.2.1.13)
MetaCyc Pathways
- pyruvate fermentation to acetate and alanine (3/3 steps found)
- pyruvate fermentation to acetate III (2/2 steps found)
- acetate and ATP formation from acetyl-CoA II (1/1 steps found)
- methoxylated aromatic compound degradation II (1/9 steps found)
- crotonate fermentation (to acetate and cyclohexane carboxylate) (1/16 steps found)
- benzoate fermentation (to acetate and cyclohexane carboxylate) (1/17 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.2.1.13
Use Curated BLAST to search for 6.2.1.13
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q72F42 at UniProt or InterPro
Protein Sequence (770 amino acids)
>DVU0373 CoA-binding domain protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710) MYNLLGSSGAETPPKCILIPRGARPSDDELMALPGEKVVLKIVSPTIIHKTEVGGVRIVP KSPEKIRSAVRRMLCEVPENYANMINLDPAHAPSAYRGLSGEALVTAIRGDLKGVLMVQF MPPDSSSFGNELIVGLRNTREFGMVVSAGLGGTDTELYAERFRKGQAIVAASCELTDGET FFELFRKTISYKKLAGLTRGQRRVVTDEQLVECFSSFIEMGRRYSPTNPDTEFVIEEMEI NPYAFTDFLMVPLDGMCRFGRPTPRESGRPIAKIDRLLHPRKIGIVGVSTTRKNFGRIIL DNVLSAGYAKEDVYLLREGADEIDGVKCFPDLASLPEKLDLFVVAVGAAQVPDLVDEVIR LDAANTAMLIPGGMGETEESRERAAKVIAAINEAHGKGDGGPVFLGANCMGVVSHPGRYD TWFIPEEKLPKNREASYHRAALVSQSGAFMLHRSSQCPELNPAYMVSMGNQTDLTLGDMV KYFKDSDKVDVIAVYAEGFNDLDGLEFCTAVREAVLAGKEVLFYKAGRTPEGKNATSGHT ASLAGDYMVCESCVRQAGAMVARNFTEFQDLFMLAETLASKRIRGNRLAAVSGAGFEAVG MADSIQSDDYQIRLASFSEATHERITAVLQAKKLAGLVSVHNPLDINPSADDEAHATVAG ILASDDGVDAVVIGLDPLSPAMHTLSGTDVPAFDMTAANGIASLLGSVAAGCDKPILGVI DGGKLYDPLRDVLNACGIPVFPVCDRAVATLAQYIEARLHADALRAEAAI