Protein Info for DVU0366 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: 5-formyltetrahydrofolate cyclo-ligase family protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 283 TIGR02727: 5-formyltetrahydrofolate cyclo-ligase" amino acids 92 to 277 (186 residues), 154.9 bits, see alignment E=1.1e-49 PF01812: 5-FTHF_cyc-lig" amino acids 92 to 277 (186 residues), 141.7 bits, see alignment E=1.3e-45

Best Hits

KEGG orthology group: K01934, 5-formyltetrahydrofolate cyclo-ligase [EC: 6.3.3.2] (inferred from 100% identity to dvu:DVU0366)

Predicted SEED Role

"5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)" in subsystem Folate Biosynthesis or One-carbon metabolism by tetrahydropterines or Serine-glyoxylate cycle (EC 6.3.3.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.3.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72F49 at UniProt or InterPro

Protein Sequence (283 amino acids)

>DVU0366 5-formyltetrahydrofolate cyclo-ligase family protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTQPRSTSPASPASPASAGNATRKPRHDAKVTAAHSAATAPVDPSSASGTSAQATGGDSR
ATGDSPPAPTGIPPAPSSIIRGAAAQDMATAKTALRREMLQRRRDLDREEAQRHGALAQA
ALLAHPAWVTARQVVLYVAVRNELDTDLLLRTAWEAGKEVLLPRCDPACSGVMCLAPCLC
AADLGPGSHGIPEPSPLRCPPVDPQSPTFAPDLAIIPGVAFDRQGNRLGYGGGYYDRFLS
TPGMSATPLVGFAHAFQIVDALPAEAWDRPVNALCTEEGLIWL