Protein Info for DVU0353 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: alcohol dehydrogenase, iron-containing (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 357 PF00465: Fe-ADH" amino acids 11 to 177 (167 residues), 99.2 bits, see alignment E=2.1e-32 PF25137: ADH_Fe_C" amino acids 190 to 281 (92 residues), 38.9 bits, see alignment E=7.7e-14

Best Hits

Swiss-Prot: 49% identical to KDNB_SHEON: 3-deoxy-alpha-D-manno-octulosonate 8-oxidase (kdnB) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: None (inferred from 100% identity to dvl:Dvul_2631)

MetaCyc: 49% identical to 3-deoxy-D-manno-octulosonate 8-oxidase (Shewanella oneidensis MR-1)
RXN-16746 [EC: 1.1.3.48]

Predicted SEED Role

"alcohol dehydrogenase, iron-containing"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.3.48

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72F61 at UniProt or InterPro

Protein Sequence (357 amino acids)

>DVU0353 alcohol dehydrogenase, iron-containing (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MYRNTKNVPYYVFGKGSFAQLGDLLAERRAEKGPVVFFVDHFFRGHDLIDRLPMQQGDQL
HFVDTTEEPKTTDIDAFTAAIRADDDRQPCCVVGIGGGAVLDTAKAVANMLTNPGKAEDY
QGWDLVKFPAVYKIGVPTLSGTGAECSRTCVLTNVQRGIKLGMNSDFTMYDQLLLDPELT
RTVPRDQYFYTGMDTYMHCIESLRGSYRNVIIDALAEKAVGMCLDIFLSDDMMSDENLEK
MMIASYLGGMSAGNVGVIHPISAGLSVVLHAHHGIANCHAMSVLEEFYPEDHKHFVAMME
RQGVTLPKGLCANLTDAQYESLVASSVVHEKPLTNALGPGFRDILTREKVISLFKAM