Protein Info for DVU0299 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: anaerobic ribonucleoside-triphosphate reductase, putative (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 681 PF03477: ATP-cone" amino acids 4 to 90 (87 residues), 68.2 bits, see alignment E=7.5e-23 TIGR02487: anaerobic ribonucleoside-triphosphate reductase" amino acids 117 to 676 (560 residues), 526.2 bits, see alignment E=5.2e-162 PF13597: NRDD" amino acids 118 to 678 (561 residues), 620.1 bits, see alignment E=4.3e-190

Best Hits

KEGG orthology group: K00527, ribonucleoside-triphosphate reductase [EC: 1.17.4.2] (inferred from 100% identity to dvu:DVU0299)

Predicted SEED Role

"Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)" in subsystem Ribonucleotide reduction (EC 1.17.4.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.17.4.2

Use Curated BLAST to search for 1.17.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72FB5 at UniProt or InterPro

Protein Sequence (681 amino acids)

>DVU0299 anaerobic ribonucleoside-triphosphate reductase, putative (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPKQIRKRDGRLETWSTDRIAEAILKALKANGIKDPLLSKRLARKVEAKLHDVEIPEQEQ
VQDNVEQVLMESRLYAVARRYIVYREKRRELREHKAAFLDITETIETYLSKADWRVNENA
NMTHSFQGLMLHLSGTLQAKYALDKYPEEVRQAHEHGYFHIHDLSFGLAGYCAGWSLRDL
LLEGFNLENRSSAGPAKHLDTALGQMINFLGTLQNEWAGAQAFNNVDTYLAPFVRNDGLT
YKQVRQAMQKFVFNLNTTSRWGGQSPFTNLSFDLVPPKHIANEPVIIGGAYQDATYGDYA
PEMEMLNRAFIEVMLDGDHNGRIFSFPIPTYNVTTDFPWESEIGDLLLKLTARYGVPYFQ
NFINSDLNPEDVRSMCCRLQMDLRELRNKVGGLFGAGDLTGSIGVVTLNLPKLAYLAQGE
EDFLDLVAEYAEIAKDSLEFKRKLITENLDRGMFPWSRRYLKNGFRGHFSTIGLVGGHEA
CMNLLGKGIDSEAGVRLMQRTLNHLREVTTRFQEETGNLYNLEATPAEGTSYRLAKIDKT
LYSEIRASGNGTPYYTNSTALPVGLTEDVFNALEHQNRLQPLYTGGTVFHTYLGEAVADP
AAIRNFIVKAFTRTKIPYLSITPTFSICKDHGYLQGEHHQCPSCGQDAEVYTRIVGYYRP
VSQWNKGKQVEYDDRVCYNGI