Protein Info for DVU0173 in Desulfovibrio vulgaris Hildenborough JW710

Name: phsA
Annotation: thiosulfate reductase (Shelley Haveman)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 698 PF04879: Molybdop_Fe4S4" amino acids 6 to 54 (49 residues), 47 bits, see alignment 3e-16 PF00384: Molybdopterin" amino acids 63 to 481 (419 residues), 117.8 bits, see alignment E=8.9e-38 PF01568: Molydop_binding" amino acids 579 to 654 (76 residues), 51.1 bits, see alignment E=1.9e-17

Best Hits

KEGG orthology group: K08352, thiosulfate reductase [EC: 1.-.-.-] (inferred from 100% identity to dvu:DVU0173)

MetaCyc: 100% identical to thiosulfate reductase (cytochrome) (Desulfovibrio vulgaris)
RXN-8339 [EC: 1.8.2.5]

Predicted SEED Role

"Thiosulfate reductase precursor (EC 1.-.-.-)" in subsystem Anaerobic respiratory reductases (EC 1.-.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.-.-.-

Use Curated BLAST to search for 1.-.-.- or 1.8.2.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72FP0 at UniProt or InterPro

Protein Sequence (698 amino acids)

>DVU0173 thiosulfate reductase (Shelley Haveman) (Desulfovibrio vulgaris Hildenborough JW710)
MAERRSVYSVCGMCSVRCPIMVDVEDGKARWIQGNPHSALKGALCARGAAGIALENDPER
PLRPLIRVGARGEGKWREASWDEALDHIASRLKIVTAEHGGRSILWSDRGGPFMDLHQAF
VRGLGSPNYCNHDASCARNVQHACRSVTGMGRKEVVYDFRNCKHIVLQTRNILEAINVGE
ANAVLDALGNGCRLSVIDIRATVSSSKAHDFFMVRPGTDYAFNLAVINVLIGEKLYDAAY
VERHVDGFDALSTFVAPYTPAWAEGETGIAAAAITDFARKLAEAAPHVVWHPGWMTARYN
DSFMVSRTAYIINALMGAIGAKGGLPLANTAKDVGRKGLKKFVDLLPKPDEKRADGVGWR
HTQFDAGPGIVNFAYDAIESGDPYPVKAYICYRHDPLMAMPDPDTLRRKLDHLDLLVSVT
FSWSDTAWFADVVLPLSTYLSRESVVAHKGGLKPQFFVRKRAMQPVADSRAEWEIISGLS
RRLGIDALAFDSIEDMWNYQLDGTGVSIADFDAKGFVELADKPLYRDIEGFTFPTPSGKI
EMVSGKWAKAGLDTLPPYVSPAHPPQDGFRVAFGRCALHTQGHTVNNPLLHEQMPENTAW
MHPTRAAALGIACGDLVEVFSARGSAGIMPVTVTPYVHPEALFMIHGFGHRLPVESRAYG
RGVADQDLMPGGLSVYDKSGGCVSLQEHFVTVRKAGVR