Protein Info for DVU0130 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: phosphoglycolate phosphatase, putative (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 220 PF00702: Hydrolase" amino acids 3 to 180 (178 residues), 87.6 bits, see alignment E=2.9e-28 PF13419: HAD_2" amino acids 7 to 184 (178 residues), 81.8 bits, see alignment E=1.2e-26 PF12710: HAD" amino acids 7 to 175 (169 residues), 33.3 bits, see alignment E=1.4e-11 TIGR01509: HAD hydrolase, family IA, variant 3" amino acids 86 to 185 (100 residues), 36.5 bits, see alignment E=5.4e-13 TIGR01549: HAD hydrolase, family IA, variant 1" amino acids 101 to 180 (80 residues), 27 bits, see alignment E=5.4e-10 PF13242: Hydrolase_like" amino acids 142 to 199 (58 residues), 31.5 bits, see alignment E=2.6e-11

Best Hits

Swiss-Prot: 34% identical to GPH_NEIMA: Phosphoglycolate phosphatase (gph) from Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

KEGG orthology group: K01091, phosphoglycolate phosphatase [EC: 3.1.3.18] (inferred from 100% identity to dvl:Dvul_2834)

Predicted SEED Role

"Phosphoglycolate phosphatase (EC 3.1.3.18)" in subsystem 2-phosphoglycolate salvage or Glycolate, glyoxylate interconversions or Photorespiration (oxidative C2 cycle) (EC 3.1.3.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.18

Use Curated BLAST to search for 3.1.3.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72FT3 at UniProt or InterPro

Protein Sequence (220 amino acids)

>DVU0130 phosphoglycolate phosphatase, putative (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MNIRACIFDLDGTLLDTLRDLAEAGNAALMAGGHPAHPVDAYRHFVGDGMETLLRRALPP
GSPEEAVRRGVERMGVAYRTAWDVFTAPYPGIMPMLEALGIRGIPMAVLSNKPHPFTVEM
VEHYFGPSRFGMVAGAKDDVPRKPHPEAALRMASAWGIAPSEVAFVGDSNVDMRTALAAG
MVAVGCPWGFRGTEELKAAGAHLLLEAPGDLLSLVATAVR