Protein Info for DVU0003 in Desulfovibrio vulgaris Hildenborough JW710

Name: gyrB
Annotation: DNA gyrase, B subunit (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 798 TIGR01059: DNA gyrase, B subunit" amino acids 9 to 798 (790 residues), 956.5 bits, see alignment E=3.5e-292 PF02518: HATPase_c" amino acids 35 to 177 (143 residues), 66 bits, see alignment E=8e-22 PF00204: DNA_gyraseB" amino acids 223 to 393 (171 residues), 187.3 bits, see alignment E=3.4e-59 PF01751: Toprim" amino acids 422 to 534 (113 residues), 59.8 bits, see alignment E=4.7e-20 PF00986: DNA_gyraseB_C" amino acids 726 to 786 (61 residues), 106.2 bits, see alignment 1.6e-34

Best Hits

KEGG orthology group: K02470, DNA gyrase subunit B [EC: 5.99.1.3] (inferred from 100% identity to dvu:DVU0003)

Predicted SEED Role

"DNA gyrase subunit B (EC 5.99.1.3)" in subsystem DNA topoisomerases, Type II, ATP-dependent or Resistance to fluoroquinolones (EC 5.99.1.3)

Isozymes

Compare fitness of predicted isozymes for: 5.99.1.3

Use Curated BLAST to search for 5.99.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72G57 at UniProt or InterPro

Protein Sequence (798 amino acids)

>DVU0003 DNA gyrase, B subunit (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTTGTGNNYTADSITILEGLSAVRKRPAMYIGSTDARGLHHLVYEVVDNSIDEAMAGFCS
KVVVKLHLDNSVTVSDNGRGIPVDMHPKEGRPAVEVVMTKLHAGGKFDNNAYKVSGGLHG
VGVSCVNALSEWLEVRVKRDGQRYGQRYARGVPQEDLRVLGASEGHGTTVRFKPDEEIFE
TNQFSYETLRKRFEELSYLNRGLEIEFIDERSGESHTFFAEGGIRQFVKDLNSGETGIHP
IVAGEGKTDGVVVDFALQYNAGYKENVLTFANNIRTKEGGTHLAGFKTALTRAINGYVKG
QADLTKKMKGTALSGDDVREGLTAVVSVKLPQPQFEGQTKTKLGNSEIAGIVAGIVYDRL
NVHFEENPKDVRLIIDKAVDAARARDAARRAKELVRRKGALSDNALPGKLADCQSKDPAL
SELFIVEGDSAGGSAKQGRDPSTQAILPLRGKILNTERTRFDKMLANKEVKALITAMGAG
IGEDDTDYDKLRYHKIVIMTDADVDGAHIRTLLLTFFFRQYQKLIESGYLYIAQPPLYRA
HNSRMERFIKDDAELNNFLLTRVSEDVEVRTPGGCSFKGTDIVRLMRSIETVAARIRDVE
TAGISRELFLGFLEYGERITPEWFEQHDGNGLRPWLAGRGYSMTAELESGDEGDRTFVVF
ENTNGHRTRIGAEFFGSRMYRSSWDALEAIRSECGGLSFTLDRKGETVGEGDMFDLQRMV
FEEARRGLNIQRYKGLGEMNPEQLWVTTMNPENRTLLQVSIEDAEEASDAFEQLMGDRVE
PRREFIVRNALAVQELDI