Protein Info for DVU3371 in Desulfovibrio vulgaris Hildenborough JW710

Name: metE
Annotation: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08267: Meth_synt_1
  • amino acids 3 to 335 (333 residues), 323.8 bits, E=1.4e-100
• TIGR01371: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
  • amino acids 6 to 781 (776 residues), 974.8 bits, E=2.6e-297
• PF01717: Meth_synt_2
  • amino acids 455 to 777 (323 residues), 497 bits, E=2.6e-153

Best Hits

Swiss-Prot: 100% identical to METE_DESVH: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K00549, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC: 2.1.1.14] (inferred from 100% identity to dvu:DVU3371)

Predicted SEED Role

"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)" in subsystem Methionine Biosynthesis (EC 2.1.1.14)

MetaCyc Pathways

• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• aspartate superpathway (20/25 steps found)
• S-adenosyl-L-methionine salvage II (3/3 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (9/12 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (13/18 steps found)
• L-methionine biosynthesis II (4/6 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (6/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (6/9 steps found)
• seleno-amino acid biosynthesis (plants) (3/5 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (5/8 steps found)
• S-adenosyl-L-methionine salvage I (2/4 steps found)
• L-methionine biosynthesis III (2/4 steps found)
• L-methionine biosynthesis I (2/5 steps found)
• superpathway of seleno-compound metabolism (6/19 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.14

Sequence Analysis Tools

See Q725Q3 at UniProt or InterPro

Protein Sequence (785 amino acids)

>DVU3371 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MRTHNLGFPRIGAGRELKKAVEGYWKGRVSRHALEGEAARLRACHWAMQRDAGIDVVPVG
DFALYDHMLDLTLMLGAIPPRFSPSGAAASPAGTGQDIDLMFRMARGEAGLSPVAPLEMT
KWFDTNYHYLVPELDADTAFAPDASPLVAQLREAQDAGFTPKAVLPGPLTWLWLARSVDG
SDRFALLPALCDAYATLLRELTSACPPACPRGYSSGGLMVQLDEPVLALDLPQTVRDLFP
AVYTRLRAAVPDATLMVASYFAPCADNLPVALNLPVDVLHLDLVRGRDDLDAALQVLGAG
EGTPGLALSLGVVDGRNVWCADIDAAVNLVRRAADSLGEDRVWVAPSCSLLHCPVDLGSE
RELDPEVARWLAFARQKCAEVRLVAEVVRGVYGPSTAASLEANREVRRQRAVSPRIHDPA
VASRLAAVTSDMEHRTSPYAERIVAQRAALHLPTLPTTTIGSFPQTPDIRAARRALRDGS
LTQDAYEAAMRDALAMMVREQEALGLDVLVHGEPERNDMVEYFGGLLQGFCITSDGWVQS
YGTRCVKPPLLYGDVSRPEPMTVAWSAYARSLTARPMKAMLTGPVTIACWSFVRDDISRE
TVLRQLALALRDEVADLESAGLAVVQVDEPALREGLPLRRAAQEAYLDAAVRAFRLATSG
VADATQLHTHMCYCDFHDIIDRIAGMDADVISLEASRSRMELLDVFATHGYPNEVGPGVY
DIHSPRVPSVDEMEALLLRAAAVLPVDRLWVNPDCGLKTREWPETRAALANMVEAARRVR
ARLDA