Protein Info for DVU3332 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: heavy metal translocating P-type ATPase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 transmembrane" amino acids 214 to 233 (20 residues), see Phobius details amino acids 239 to 260 (22 residues), see Phobius details amino acids 550 to 569 (20 residues), see Phobius details amino acids 575 to 591 (17 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 47 to 592 (546 residues), 513.8 bits, see alignment E=1e-157 TIGR01494: HAD ATPase, P-type, family IC" amino acids 70 to 562 (493 residues), 232.5 bits, see alignment E=1.1e-72 PF00122: E1-E2_ATPase" amino acids 100 to 268 (169 residues), 130.5 bits, see alignment E=7.5e-42 PF00702: Hydrolase" amino acids 286 to 505 (220 residues), 126.5 bits, see alignment E=2.6e-40 PF08282: Hydrolase_3" amino acids 477 to 526 (50 residues), 21.6 bits, see alignment 2.5e-08

Best Hits

KEGG orthology group: K01552, [EC: 3.6.3.-] (inferred from 100% identity to dvu:DVU3332)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4); FUPA32 P-type ATPase" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-, 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.- or 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q725U3 at UniProt or InterPro

Protein Sequence (606 amino acids)

>DVU3332 heavy metal translocating P-type ATPase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MGLGRLLRYLLLRPLLPAPVRMATALLRATPFITQGLRSLARGRLSVDVLDAAAIGVSLL
RRDFRSVGTITFLLAVGEALEAWTRKASREGLAASLALDVDTIWVRRGEAEVQVPLASLA
DGDVVVVRAGGAIPVDGVVVDGEALVNQASMTGEPLGVMRVAGAAVFAGTVVEEGTLGIR
ATGVGHETRLSRIVDFIERSEALKAGIQGKAERLADAVVPFSFALAASVWLLTRDPARAA
SVLLVDYSCAIRLATPLAILSAMREGASRGVLVKGGRFLEGLAAADAVVFDKTGTLTEAR
PRVTAVIPAEGFERDDVLRIAACLEEHFPHPVARAVVHKAEEQHLQHHEEHAEVEYVVAH
GIASRLHGERVLVGSHHFVHEDEGVPVSTMDEAVATLSAQGHSVLYLAIGGRLAGVLGIE
DPLRPEAPAVVTALRQSGVRRILMLTGDGERTAAAVAARLGIDEYRAQVLPADKAFVVQE
LKAQGHTVIMVGDGINDAPALSSADVGVTLRDGTDLAREVADVVLLHCDLTDLAVARELG
RRTLARIRHGFISTMTLNTLFLAAGLAGLARPGVAAVLHNLTTVGVALNAMRPLLPAMER
AGGDTA