Protein Info for DVU3284 in Desulfovibrio vulgaris Hildenborough JW710

Name: b2975
Annotation: L-lactate permease (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 543 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 40 to 60 (21 residues), see Phobius details amino acids 71 to 92 (22 residues), see Phobius details amino acids 115 to 142 (28 residues), see Phobius details amino acids 153 to 178 (26 residues), see Phobius details amino acids 198 to 216 (19 residues), see Phobius details amino acids 222 to 241 (20 residues), see Phobius details amino acids 250 to 268 (19 residues), see Phobius details amino acids 296 to 314 (19 residues), see Phobius details amino acids 357 to 378 (22 residues), see Phobius details amino acids 397 to 418 (22 residues), see Phobius details amino acids 430 to 449 (20 residues), see Phobius details amino acids 513 to 536 (24 residues), see Phobius details TIGR00795: transporter, lactate permease (LctP) family" amino acids 5 to 536 (532 residues), 579.4 bits, see alignment E=4e-178 PF02652: Lactate_perm" amino acids 16 to 534 (519 residues), 581.7 bits, see alignment E=8e-179

Best Hits

KEGG orthology group: K03303, lactate transporter, LctP family (inferred from 100% identity to dvu:DVU3284)

Predicted SEED Role

"L-lactate permease" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q725Z0 at UniProt or InterPro

Protein Sequence (543 amino acids)

>DVU3284 L-lactate permease (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MNWIQNYDPLSSALGSALVAAIPLFILFYMLAVKRAKGHVAAFLGTTSAIVLAIAVWGMP
VSLAASATLYGAAYGLFPIVWIVITAVWVYNMTVESGEFEIIKDSLARLTDDRRLQAIFI
AFAFGSFIEGTAGFGTPVAITASMLVGLGFNPLYAAGICLIANTAPVAFGAIGIPIIVAG
QVTGLDTMHISQIVGRQLPFLSVIVPMWLCVTMCGFKRAMEVLPAVAVAGVCFAGSQFVF
SNYHGPTLPDIMSAIVTIIGLVLLLRVWKPATTWRFPGEAEVELSAVSQYSAGDVIRAWM
PYIILAVMVFFWGLDGVKKVLDGIFSVSVDWPGLHNLIEKTAPIAAKNAPYAAKYKLNLI
SAGGTAILLSGLLAVPVMPKYGFDKAIACLFRTFYQLRFPVVTIAMILGLAQIMNYSGMS
STLGIAFTKTGWLFPFFAPLLGWLGVFLTGSDTSSNALFGGMQRATAEAVGVDPHLTVAA
NSSGGVTGKMISPQSISVATASTNMVGQEGSLFRFTLGHSIAMTLFVCVLTLLQAYPLKG
MLP