Protein Info for DVU3248 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: AcrB/AcrD/AcrF family protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1047 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 345 to 364 (20 residues), see Phobius details amino acids 371 to 393 (23 residues), see Phobius details amino acids 399 to 421 (23 residues), see Phobius details amino acids 442 to 462 (21 residues), see Phobius details amino acids 474 to 498 (25 residues), see Phobius details amino acids 540 to 559 (20 residues), see Phobius details amino acids 870 to 888 (19 residues), see Phobius details amino acids 895 to 915 (21 residues), see Phobius details amino acids 924 to 946 (23 residues), see Phobius details amino acids 972 to 992 (21 residues), see Phobius details amino acids 1002 to 1026 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 2 to 1026 (1025 residues), 1103.1 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 2 to 1045 (1044 residues), 1190.5 bits, see alignment E=0

Best Hits

Swiss-Prot: 46% identical to BEPG_BRUSU: Efflux pump membrane transporter BepG (bepG) from Brucella suis biovar 1 (strain 1330)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 100% identity to dvl:Dvul_0141)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q725M1 at UniProt or InterPro

Protein Sequence (1047 amino acids)

>DVU3248 AcrB/AcrD/AcrF family protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MFAKFFIDRPILANVIGIVLILIGVVSVMLLPISQYPEITPPTVEVKAIYPGSNSLVLAD
TVGAPIEQEVNGVEGMLYMSSKSANDGTYTLTITFALGTNIDMATVLVQNRVNVAMARLP
DEVKRQGVTVKKKSTAILQVVTLTSPDGSYDDLFLSNFASLRIRDELARIPGVGEATVFG
AASYSMRVWLDAPRLKSMGLTTKDVVNAISEQNVQVAAGQIGAQPAPDTQNFQFTVQTQG
RLSNVEEFEDIIIRTATSGPAGRVVRVRDVARVELGGQTYDLYAQKNGKPAALVIIYQLP
GANALDVAQQVNARMKTLGNDFPQGVAWDVPYDTTRFVEAAIEQVYHTLFEAAVLVLAVI
LIFLQDWRATLVPASVVPITILGGFMAMMGLGFSVNLVTLFGIILAIGIVVDDAIIVVEG
AAHHMEHGDPAREATIKAMMQLFGPIIGITLVLSCVFIPASFMSGITGQLYRQFALVIAS
TALVSALLAATLTPAQCALFLKPIVPGRNAFYRGFNKSYDAVENLFVTILRTMVRHAKTT
MLVFVGLITATFWAFTSLPTGFLPDEDQGYALVAVQLPGAASQARTREVTTRLDAIFSET
QGVADWITFGGMSILNGANTSNSATVFVMYKDWSERGALTQERIVADLRRKVASIQEGMV
IVVTPPPIQGLGNAGGFEMMVQDRAALGAQQLETVAYSMMAAARGQSGLGNVSTTYNART
PQLFVNVDRTQVKNYDVQLNDVFSTMQSYLGSSYVNDFNKFGKTYQVRVQADSRYRLTAE
DIGRLEVRNAQGGMVPLGAVTDVKDVVGPDVVTRYNLYPAASLIGAAAPGFSSGQALALM
EDMARKTLPQSMGFEWTTMAYQEKATGNEAFAVFGFAVLLVFLVLAAQYESWSAPAAIIM
VVPLALLGTSIAVATRGMDNNVYTQIGIVLLIALASKNAILIVEFARELRLQKGMSIQDA
AVEGARARFRPILMTSFAFILGVVPLLTASGAGSASQRALGTAVFGGMLASTFLAVLFVP
VFFTVIQTLSEGLSRQSSPSQKNINHK