Protein Info for DVU3176 in Desulfovibrio vulgaris Hildenborough JW710
Annotation: UDP-glucose/GDP-mannose dehydrogenase family protein (TIGR)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 62% identical to CAPL_STAAU: Protein CapL (capL) from Staphylococcus aureus
KEGG orthology group: K02474, UDP-N-acetyl-D-galactosamine dehydrogenase [EC: 1.1.1.-] (inferred from 100% identity to dvu:DVU3176)MetaCyc: 63% identical to UDP-N-acetylgalactosamine 6-dehydrogenase (Pseudomonas aeruginosa)
UDP-N-acetylglucosamine 6-dehydrogenase. [EC: 1.1.1.136]; 1.1.1.136 [EC: 1.1.1.136]
Predicted SEED Role
"UDP-glucose dehydrogenase (EC 1.1.1.22)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) or Teichuronic acid biosynthesis (EC 1.1.1.22)
MetaCyc Pathways
- colanic acid building blocks biosynthesis (10/11 steps found)
- UDP-α-D-xylose biosynthesis (2/2 steps found)
- UDP-N-acetyl-α-D-galactosaminuronate biosynthesis (2/2 steps found)
- UDP-α-D-glucuronate biosynthesis (from UDP-glucose) (1/1 steps found)
- superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
- UDP-sugars interconversion (4/9 steps found)
- UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronate biosynthesis (1/5 steps found)
- teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
- superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Benzoate degradation via CoA ligation
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of type II polyketide products
- Biosynthesis of unsaturated fatty acids
- Bisphenol A degradation
- Butanoate metabolism
- C21-Steroid hormone metabolism
- Fructose and mannose metabolism
- Glycine, serine and threonine metabolism
- Insect hormone biosynthesis
- Linoleic acid metabolism
- Nucleotide sugars metabolism
- Pentose and glucuronate interconversions
- Polyketide sugar unit biosynthesis
- Retinol metabolism
- Starch and sucrose metabolism
- Tetrachloroethene degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.-, 1.1.1.22
Use Curated BLAST to search for 1.1.1.- or 1.1.1.136 or 1.1.1.22
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q725J7 at UniProt or InterPro
Protein Sequence (440 amino acids)
>DVU3176 UDP-glucose/GDP-mannose dehydrogenase family protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710) MNEQTSFDDIASGRTAVAVVGLGYVGLPLAVALARHFRVIGFDIQQNRVDELSSGHDRTG EVDDASLAATPALFTTDAARLGEAGVIIVAVPTPIDNHRNPDLGPVEKSSITVGRHMKAG CVVVYESTVYPGVTEEVCVPILERESGLVFGRDFTVGYSPERINPGDKVHTLETIMKIVS GSDAATADLLEKVYGSVVTAGIHKAASIKVAEAAKVIENTQRDLNIALMNELSIIFDRLG IDTLEVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTFKAEELGYHPQVILAGRRINDGM GKHVAEMTVKRMIRSGCRVAGARVGVLGLTFKENVPDLRNTRVIDVVRELEEYGVTVLVH DPFADPAEAMHEYGLTLAHLKDFQQLDALVVTVPHDVYRAMDLVQVRRWCASSGTPPLLD VRGTFNPGTAREAGFDYWRL