Protein Info for DVU3133 in Desulfovibrio vulgaris Hildenborough JW710

Name: glpF
Annotation: glycerol uptake facilitator protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 251 transmembrane" amino acids 14 to 35 (22 residues), see Phobius details amino acids 46 to 67 (22 residues), see Phobius details amino acids 87 to 107 (21 residues), see Phobius details amino acids 118 to 137 (20 residues), see Phobius details amino acids 143 to 161 (19 residues), see Phobius details amino acids 169 to 193 (25 residues), see Phobius details amino acids 220 to 239 (20 residues), see Phobius details PF00230: MIP" amino acids 3 to 239 (237 residues), 142.1 bits, see alignment E=1.2e-45 TIGR00861: MIP family channel proteins" amino acids 12 to 239 (228 residues), 183.9 bits, see alignment E=1.9e-58

Best Hits

Swiss-Prot: 46% identical to GLPF3_LACPL: Glycerol uptake facilitator protein 3 (glpF3) from Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

KEGG orthology group: K02440, glycerol uptake facilitator protein (inferred from 100% identity to dvu:DVU3133)

Predicted SEED Role

"Glycerol uptake facilitator protein" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization or Glycerol fermenation to 1,3-propanediol

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q726H5 at UniProt or InterPro

Protein Sequence (251 amino acids)

>DVU3133 glycerol uptake facilitator protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MKEISLGKEMLSEFMGTMVLIIFGAGNVAMTVLFGKTLNITWDNITFGWGLAVLLGIMAG
LPSGAHINPAVSLALAATGRFPWRKVLPYSVAQVAGGFAGAAIVFLDFKAKWLGVDPQLA
STAGIFCTFPAITTSYLPGFIDQIIGTAVLMFGILAIGDFAGKNNVGWMGPVLVAALIVA
IGMSLGAMHGYAINPARDFGPRFFALVAGFTQPNLMEPGIVLVPIVGPIIGGPLGAFIYD
WTTGAVNKAQG