Protein Info for DVU3121 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: aminotransferase, class V (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 34% identical to SPYA_PONAB: Serine--pyruvate aminotransferase (AGXT) from Pongo abelii

KEGG orthology group: K00830, alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase [EC: 2.6.1.44 2.6.1.45 2.6.1.51] (inferred from 100% identity to dvl:Dvul_0262)

MetaCyc: 34% identical to Serine--pyruvate aminotransferase (Homo sapiens)
Serine--pyruvate transaminase. [EC: 2.6.1.51]; Alanine--glyoxylate transaminase. [EC: 2.6.1.51, 2.6.1.44]

Predicted SEED Role

"Serine--pyruvate aminotransferase (EC 2.6.1.51) / L-alanine:glyoxylate aminotransferase (EC 2.6.1.44)" in subsystem Photorespiration (oxidative C2 cycle) or Pyruvate Alanine Serine Interconversions or Serine-glyoxylate cycle (EC 2.6.1.44, EC 2.6.1.51)

MetaCyc Pathways

glycine biosynthesis III (1/1 steps found)
L-serine biosynthesis II (3/4 steps found)
photorespiration I (6/9 steps found)
photorespiration III (6/9 steps found)
photorespiration II (6/10 steps found)
formaldehyde assimilation I (serine pathway) (7/13 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.45

Use Curated BLAST to search for 2.6.1.44 or 2.6.1.45 or 2.6.1.51

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q726I6 at UniProt or InterPro

Protein Sequence (376 amino acids)

>DVU3121 aminotransferase, class V (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MRTQEGPLGHPLRNIKALLLMGDGPSGVPDSVYSALALPTVGPLDPGFDEILDRLQGQLR
NIFNVSDGVCAVLDGPAAVGMETCLVNLLEPGERLLVLDNGMGGERLRETAQRLGLAVDV
LTVPWGDPVLSEQVAQRLARSDYHAVVMVHAESSTGVRSPVGAVGDLVSMHGALFIVDCE
TSLGGMDVDMARWRADALFASSHKCLSCPPGLAPVAFSMRALDRVGRRRTPIPGRYFDIA
LHLDYWQGAPRVCHLMPSVNLLYALHMALEGVLNEGLPNVFARHRAAHEQLVTGLAALGL
RPLADVPWRLPMLHVVPAPEGVDAEDVRGRLRAEHGIEIGGGVGRLAGRVWRIGLMGHSA
RTTNVVALLEALGRLL