Protein Info for DVU3067 in Desulfovibrio vulgaris Hildenborough JW710

Name: hypF
Annotation: [NiFe] hydrogenase maturation protein HypF (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 786 PF00708: Acylphosphatase" amino acids 9 to 92 (84 residues), 77.8 bits, see alignment E=1.6e-25 TIGR00143: carbamoyltransferase HypF" amino acids 12 to 774 (763 residues), 796.6 bits, see alignment E=1.1e-243 PF07503: zf-HYPF" amino acids 111 to 143 (33 residues), 59.8 bits, see alignment (E = 4.4e-20) amino acids 161 to 193 (33 residues), 64.1 bits, see alignment (E = 2.1e-21) PF01300: Sua5_yciO_yrdC" amino acids 214 to 408 (195 residues), 134.1 bits, see alignment E=1e-42 PF17788: HypF_C" amino acids 423 to 518 (96 residues), 113 bits, see alignment E=2.4e-36 PF22521: HypF_C_2" amino acids 528 to 773 (246 residues), 255.3 bits, see alignment E=1.8e-79

Best Hits

KEGG orthology group: K04656, hydrogenase maturation protein HypF (inferred from 100% identity to dvu:DVU3067)

Predicted SEED Role

"[NiFe] hydrogenase metallocenter assembly protein HypF" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q726N9 at UniProt or InterPro

Protein Sequence (786 amino acids)

>DVU3067 [NiFe] hydrogenase maturation protein HypF (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPPTPLRRRFVVSGQVQGVGFRPFVFRIATGHALTGTVSNTSEGVFIEVQGPHEAVEAFG
DDLVGKLPPLAQVVSCEHEDLPLVAGETDFIIVASSGGHGHQVLISPDMAVCDDCLADMR
DPAGRRYRYPFTNCTNCGPRYTITRSIPYDRDKTSMACFPLCPACRAEYEDPMDRRFHAQ
PNACPVCGPRLWLTARDGTTLAEGDYAITVTAHVLNTGRIAAIKGLGGFHLACDATDDAA
VTTLRERKRRPHKPLAVMVPDMDTVRRIAAPTPDEERLILSQERPIVLCRARDDGPLASA
VSPDTDHVGVMLPYTPLHHVLFDTLADLRREGGTSSRRTPSASDVCALVMTSGNASNEPI
CLGNRESLRRLAHIADAFLLHDRDILIRTDDSVVRAVQGEDGPLFMRRARGFVPRPVRLP
DSGPCVLATGPELKNTLCITRNDMAFVSQHIGDMHNLETLGFFREIAAHLADILQVEPEA
VVRDLHPDYMTTRWAEDCGLPVLALQHHYAHAYSVLAENGHEGPALCVTLDGTGYGDDGT
IWGGEFLYVDSLELEHERLAHFSRLPLPGGETAIREPWRIAQGALWRLGMFEPDSRVWPW
LPHREEASRMVGLMLDKGVNTPMASSCGRLFDAVSAMLGLCESITYEGQAAILLERIQDM
SETTPYPCPLKDGVQPMVLDTAQLFLHAYVDWAMETPPGIIARRFHLGLIQGVADLAASL
CGAMGLTTVGLSGGVMQNLTLAAGLPEALRARGLVPLVHRTLPPNDGCISLGQAAWGRRR
LQRDNA