Protein Info for DVU2943 in Desulfovibrio vulgaris Hildenborough JW710

Name: pyrE
Annotation: orotate phosphoribosyltransferase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00336: orotate phosphoribosyltransferase
  • amino acids 14 to 179 (166 residues), 138.9 bits, E=7.5e-45
• PF00156: Pribosyltran
  • amino acids 111 to 159 (49 residues), 27.2 bits, E=1.1e-10

Best Hits

Swiss-Prot: 46% identical to PYRE_AQUAE: Orotate phosphoribosyltransferase (pyrE) from Aquifex aeolicus (strain VF5)

KEGG orthology group: K00762, orotate phosphoribosyltransferase [EC: 2.4.2.10] (inferred from 100% identity to dvu:DVU2943)

Predicted SEED Role

"Orotate phosphoribosyltransferase (EC 2.4.2.10)" in subsystem De Novo Pyrimidine Synthesis (EC 2.4.2.10)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (6/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• UMP biosynthesis I (5/6 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.10

Sequence Analysis Tools

See Q727B2 at UniProt or InterPro

Protein Sequence (186 amino acids)

>DVU2943 orotate phosphoribosyltransferase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MQELKKRLARLLVEKSYREGDFTLTSGRKSTYYFDCKQTALHAEGSWLIGTLFNELLKDV
DIVGVGGMTLGADPLISATTVISHEKGRPLAGFIVRKQPKGHGTDQYVEGLANFKPGDKV
AMLEDVVTTGGSLLKACERVKAAGLDIVAVCTVLDREEGGRQAILDAGYELISVFTRDEL
VAAARS