Protein Info for DVU2816 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: multidrug resistance protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1070 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 394 to 414 (21 residues), see Phobius details amino acids 437 to 458 (22 residues), see Phobius details amino acids 470 to 496 (27 residues), see Phobius details amino acids 537 to 558 (22 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 925 to 950 (26 residues), see Phobius details amino acids 971 to 992 (22 residues), see Phobius details amino acids 1004 to 1027 (24 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1032 (1032 residues), 1711.4 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1026 (1026 residues), 1317.6 bits, see alignment E=0

Best Hits

Swiss-Prot: 65% identical to ACRB_ECOLI: Multidrug efflux pump subunit AcrB (acrB) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 65% identity to abo:ABO_0964)

MetaCyc: 65% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q727N9 at UniProt or InterPro

Protein Sequence (1070 amino acids)

>DVU2816 multidrug resistance protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MARFFIDRPVFAWVIAIIIMLAGALSILSLPVSQYPKIAPTSVNISASYPGASAKTVEDT
VTQVIEQKMKGIDSLRYMSSTSDATGQVSITLTFDASTDPDIAQVQVQNKLALATPMLPE
AVQRQGITVNKSTSSFLMIIALASDDPSLTGRDLSDYAATYLLDPISRVDGVGETQLFGA
QYAMRVWLDPHKLMNYRMTPADVRSAITAQNTQISVGQIGGTPAVPGQGMSFTILSQSLL
QTREQFERIVLRVEQDGSTVRLADVARVELGSENYDAVSHFNGKPSTGIAIKLATGANAL
DTVKRVRTTMEGLAKNLPEGIRCVFPYDTTPFVRVSIEEVVKTLAEAIVLVFLVMYLFLQ
NIRATIIPTIAVPVVLLGTFGALAAFGFSINMLTMFGVVLAIGLLVDDAIVVVENVERIM
TEEGLPPREATRKSMGEITGALVGIALVLSAVFIPMAFIKGSSGVIYRQFSLTIVSAMTL
SVVVALVLTPALCATFLKPLHKHEHQAQGGFFGWFNRMFDRTSRGYRKQVTGVTGRVGRT
MCIYALLLAGTAFLFMRLPTSFLPEEDQGVIFSLVQLPTGSPQEKTLEVLKKLEHHYLVD
EKETVNSLFTVAGFSFAGRGQNAGLAFVQLKPWDERKGEGMSAAAVAGRAMRAFSRIRNS
VVYAFTPPAVQELGNASGFNLFLQDREGVGHEALMQARNQLLGMAAQNPAIAVLRPNGME
DTPQFRIDVDAAKAGAHGLTMADVNGVLSTALGGAYVNDFIDRGRVKKVYLQGDAPFRMM
PEDINAWHVRNAQGNMVPFSAFSTASWTYGSPRLERYNGLPAVELVGSAAPGKSTGEAMQ
AVEDMAAKLPPGVGISWTGLSYQERMSGSQAPALYAISILVVFLCLAALYESWSVPTAVI
LVVPLGIIGALMATLGRGLNNDVFFQVGLLTTIGLAAKNAILIVEFAMHLVKSGRPLLDA
TAEAARLRLRPILMTSLAFLLGVLPMAISTGAGSGSQRAIGTGVMGGMFSATVLAVYFVP
VFFVMVYRFAMRKRGGGPEGGGHGSDAHGGDPLATAQDDGQAKASGEVAR