Protein Info for DVU2811 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: formate dehydrogenase, beta subunit, putative (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13247: Fer4_11
  • amino acids 66 to 170 (105 residues), 123.7 bits, E=3.2e-40

Best Hits

Swiss-Prot: 100% identical to FDNGB_DESVH: Formate dehydrogenase 2 subunit beta (cytochrome c-553) (DVU_2811) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K00124, formate dehydrogenase, beta subunit [EC: 1.2.1.2] (inferred from 100% identity to dvu:DVU2811)

MetaCyc: 100% identical to formate dehydrogenase 3 subunit beta (Desulfovibrio vulgaris)
1.2.2.3-RXN [EC: 1.17.2.3]; 1.17.2.3 [EC: 1.17.2.3]

Predicted SEED Role

"Formate dehydrogenase O beta subunit (EC 1.2.1.2)" in subsystem Formate dehydrogenase or Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (7/8 steps found)
• formate oxidation to CO₂ (1/1 steps found)
• reductive glycine pathway of autotrophic CO₂ fixation (6/9 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• purine nucleobases degradation I (anaerobic) (5/15 steps found)
• superpathway of C1 compounds oxidation to CO₂ (2/12 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.17.2.3 or 1.2.1.2

Sequence Analysis Tools

See Q727P4 at UniProt or InterPro

Protein Sequence (219 amino acids)

>DVU2811 formate dehydrogenase, beta subunit, putative (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPKAFLIDTTRCTACRGCQLACKEWHDLPANVTKQRGSHQNPPDLNPNNLKIVRFNERMN
EKGVVIWNFFPDQCRHCVTPVCVDVADMAVPGAMIKDKKTGAVLATEKSAKLSPADAKAV
AEACPYNIPRIDPKTKRITKCDMCFDRVSAGMQPICVKTCPTGTMAFGERDEMLALAEKR
LADAKTRFPKAHLVDVEDVSVIYLLAEEKEHYYEYAGFM