Protein Info for DVU2521 in Desulfovibrio vulgaris Hildenborough JW710
Name: aroK-2
Annotation: shikimate kinase (TIGR)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 33% identical to AROK_HAEDU: Shikimate kinase (aroK) from Haemophilus ducreyi (strain 35000HP / ATCC 700724)
KEGG orthology group: K00891, shikimate kinase [EC: 2.7.1.71] (inferred from 100% identity to dvl:Dvul_0723)MetaCyc: 75% identical to homoserine kinase (Desulfovibrio vulgaris)
Homoserine kinase. [EC: 2.7.1.39]
Predicted SEED Role
"Shikimate kinase I (EC 2.7.1.71)" in subsystem Benzoate transport and degradation cluster or Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 2.7.1.71)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (17/18 steps found)
- superpathway of L-isoleucine biosynthesis I (12/13 steps found)
- superpathway of L-tryptophan biosynthesis (12/13 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- aspartate superpathway (20/25 steps found)
- superpathway of L-phenylalanine biosynthesis (9/10 steps found)
- superpathway of L-tyrosine biosynthesis (9/10 steps found)
- superpathway of L-threonine biosynthesis (6/6 steps found)
- chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
- chorismate biosynthesis II (archaea) (10/12 steps found)
- chorismate biosynthesis I (6/7 steps found)
- L-threonine biosynthesis (2/2 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (13/18 steps found)
- L-methionine biosynthesis II (4/6 steps found)
- superpathway of chorismate metabolism (31/59 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Glycine, serine and threonine metabolism
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.7.1.71
Use Curated BLAST to search for 2.7.1.39 or 2.7.1.71
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q728T1 at UniProt or InterPro
Protein Sequence (180 amino acids)
>DVU2521 shikimate kinase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710) MMTRREGARLFEGCCVTIIGMAGAGKTTVGRELARQMDWAHVDTDSLIEATYGTVLQNVA DSMSKEAFLDVEAGIICRIGAKRAVLSTGGSVVYRAEAMRHLASLGPVVYLDVSLPLILE RIARNPDRGLAIAPGQTIEDLYNERKALYETYQDFTLTADTLTPEECGRAILSWLETADA