Protein Info for DVU2504 in Desulfovibrio vulgaris Hildenborough JW710

Name: murG
Annotation: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 365 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 69 to 86 (18 residues), see Phobius details amino acids 95 to 113 (19 residues), see Phobius details TIGR01133: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase" amino acids 1 to 352 (352 residues), 306.9 bits, see alignment E=8.7e-96 PF03033: Glyco_transf_28" amino acids 4 to 142 (139 residues), 103.2 bits, see alignment E=1.3e-33 PF04101: Glyco_tran_28_C" amino acids 186 to 348 (163 residues), 131.4 bits, see alignment E=3.5e-42

Best Hits

Swiss-Prot: 100% identical to MURG_DESVH: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (murG) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K02563, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC: 2.4.1.227] (inferred from 100% identity to dvl:Dvul_0741)

Predicted SEED Role

"UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227)" in subsystem Peptidoglycan Biosynthesis (EC 2.4.1.227)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.1.227

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q728U8 at UniProt or InterPro

Protein Sequence (365 amino acids)

>DVU2504 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MRRVILTTGGTGGHIFPALAVAEEIRARYPECSVLFMGGLYGPEADLAARAGLDFVGLPV
RGVLGRGVRAIGAAFGMAAGIARAYAVMGRFDPDIVLGFGGYAAFAGVLAARLRGRPAAI
HEQNSVPGLTNRVLSRVVPRVFLSLPDTLGAFPPQKTCLAGNPVRASIVACGAERSDPRP
DHVRRLLVMGGSLGARAINDAVVSSLPALAEAGVEVWHQTGAADWERIRKAYAETGHGEG
RVEAFIDDVASAYAWADLVLCRAGATSVAELAVAGKPAVLVPYPFATHDHQTHNARWLVS
RGAAVLLEQKDISMTDVPALLVGLLSDRARLNRMAVSARAQGRPDAAAAVVDGLVELLKT
TPRAR