Protein Info for DVU2285 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: L-lactate permease family protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 50 (21 residues), see Phobius details amino acids 62 to 83 (22 residues), see Phobius details amino acids 104 to 124 (21 residues), see Phobius details amino acids 130 to 151 (22 residues), see Phobius details amino acids 158 to 176 (19 residues), see Phobius details amino acids 182 to 204 (23 residues), see Phobius details amino acids 211 to 229 (19 residues), see Phobius details amino acids 238 to 258 (21 residues), see Phobius details amino acids 279 to 299 (21 residues), see Phobius details amino acids 319 to 338 (20 residues), see Phobius details amino acids 359 to 382 (24 residues), see Phobius details amino acids 396 to 414 (19 residues), see Phobius details amino acids 480 to 501 (22 residues), see Phobius details TIGR00795: transporter, lactate permease (LctP) family" amino acids 3 to 497 (495 residues), 439.1 bits, see alignment E=1.3e-135 PF02652: Lactate_perm" amino acids 5 to 496 (492 residues), 461.4 bits, see alignment E=4.5e-142 PF03553: Na_H_antiporter" amino acids 330 to 468 (139 residues), 30.7 bits, see alignment E=2e-11

Best Hits

KEGG orthology group: K03303, lactate transporter, LctP family (inferred from 100% identity to dvl:Dvul_0970)

Predicted SEED Role

"L-lactate permease" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q729R4 at UniProt or InterPro

Protein Sequence (506 amino acids)

>DVU2285 L-lactate permease family protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MDSMQLVLALSPIVWLIFSLIVLKLPAYRTCALTLAATVCIAVFGPWHMAPLSAGTAALE
GAALGLWPIMVVIVAAVFTYNLAQHTGSMNVITRMLSGITTDKRLLVLIVAWGFGGFLEG
VAGYGTAVAIPASILAAMGFQPMFAAVICLVANTVPTAFGAIGIPIVTMASVTGLPVETI
SYYTALQLSVFIILITFLLVILTAGFKGIRGVFWATLVSGVAFALPQLYTAKYMGAELPC
LIGSVCSMVATIVWARIFHRDTAAVETEPLPTADKVKAWLPYIFVFSFIILCSNLFPLIK
DTLGAVKTTVVIHGDTPFTFKWLATPGSLIIIATYLGGMIQGVRFGEITGVLVKTARKLA
FSAVTVVSIVALAKVMASSGMINTLAVAVADATSSYFPLIAPLLGALGTFVTGSDTSSNV
LFGQLQMEVANRISIDRAWIVAASAAGATAGKMISPQSIAVATAATGLVGSEGRIMNRTL
AVCVGYVLILGTLVYVAIPYLHMLQG