Protein Info for DVU2083 in Desulfovibrio vulgaris Hildenborough JW710

Name: relA
Annotation: GTP pyrophosphokinase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 717 TIGR00691: RelA/SpoT family protein" amino acids 26 to 710 (685 residues), 775.4 bits, see alignment E=2.5e-237 PF13328: HD_4" amino acids 26 to 175 (150 residues), 181 bits, see alignment E=6.3e-57 PF01966: HD" amino acids 45 to 144 (100 residues), 44.7 bits, see alignment E=7e-15 PF04607: RelA_SpoT" amino acids 235 to 344 (110 residues), 145.1 bits, see alignment E=4.6e-46 PF02824: TGS" amino acids 387 to 446 (60 residues), 80.2 bits, see alignment 4.2e-26 PF19296: RelA_AH" amino acids 472 to 543 (72 residues), 53.5 bits, see alignment E=8e-18 PF28438: RelA_RIS" amino acids 572 to 630 (59 residues), 87.7 bits, see alignment 1.5e-28 PF13291: ACT_4" amino acids 635 to 711 (77 residues), 70.4 bits, see alignment E=7.6e-23 PF01842: ACT" amino acids 644 to 704 (61 residues), 37.6 bits, see alignment 6.9e-13

Best Hits

KEGG orthology group: K00951, GTP pyrophosphokinase [EC: 2.7.6.5] (inferred from 100% identity to dvl:Dvul_1146)

Predicted SEED Role

"GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)" in subsystem Stringent Response, (p)ppGpp metabolism (EC 2.7.6.5, EC 3.1.7.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.6.5 or 3.1.7.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72AB4 at UniProt or InterPro

Protein Sequence (717 amino acids)

>DVU2083 GTP pyrophosphokinase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MIRIQEIVDKVAASHKDADISLIQRAYVYAAAGHAGQTRLSGEPYLSHPLAVADLLAEMH
FDEATVAAGLLHDTVEDTDAGIEDIDREFGEEVADIVDGVTKISQMTFDSKEEAQAENIR
KMILAMSHDIRVLMVKLADRLHNMRTLDFQKSHKQQSIAQETLDIYAPLANRLGLHRIKL
ELEDLGLRYTKPDVFAQITDWLDENQMVERNLIDKVIARIREVLDANGIEGEVRGRIKHK
SSIYKKMTQQGLALDEMHDIIAFRVIVADLRDCYAVLGLMHAQWKPVHGRFKDYISMPKA
NGYQSLHTTVIGPEGERIEIQIRTREMHRMAEHGVASHWLYKDAGRVNPRDVAQFTWLRE
ILDRQKHEADSKEFMHSLRLDLFKDEVYVFTPRGDVKELPEGATPIDFAYLIHSQVGDHC
AGAKVNGKLVPLGTPLVSGDTIEVITDPNRHPSRDWLKIVKTAKARSRIQHFIRTEERAR
SISLGREMLEKEGRRMGINVSKAIREGDFDAVVKEFSLGSVDDLLSSVGYARHTPKRILR
RLQAHISPPAPEEVKAQEPAPTAPPDRKSESVSIRGVDDVLVRFARCCNPVPGDAIVGYI
SRGRGVTVHTSDCPNVQGMEPERLISVFWDGHEDKPFPARIHLLCRNEKGVLAQISALLA
EANINIDSGTMHSLVDGHSEVELMVEVRDVAHLYHTMDRLRKLPAVLEVIRAAAHME