Protein Info for DVU1960 in Desulfovibrio vulgaris Hildenborough JW710

Name: cheA-2
Annotation: chemotaxis protein CheA (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 697 PF01627: Hpt" amino acids 7 to 99 (93 residues), 54.7 bits, see alignment E=2e-18 PF02895: H-kinase_dim" amino acids 311 to 371 (61 residues), 46.1 bits, see alignment 1.1e-15 PF02518: HATPase_c" amino acids 419 to 556 (138 residues), 53.3 bits, see alignment E=7.3e-18 PF01584: CheW" amino acids 562 to 685 (124 residues), 65.8 bits, see alignment E=6.4e-22

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 100% identity to dvu:DVU1960)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72AN2 at UniProt or InterPro

Protein Sequence (697 amino acids)

>DVU1960 chemotaxis protein CheA (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MIDRPAVMRLFGDEARELLIDMESLFLELEQTPDDRALVARVFRTMHTLKGSGAMFGYTE
AARVAHALEDVFDRVRHGRLPLTSELLGLCLEAKDHLQTLLEGDPADVPVAVREASDALM
LRIAAFEHDEADVDDGQAVHAAKPYDTGVPEHMTISGDATGEAEVCLWVRLTPADDWMWR
GLDPLRLLDSFRGYGPFEVVPVFADGGLEHVGEVPFPVRWEGVLTGRVSADVLRQDYAWL
LDSENLSIMSLGKRSDCPPVRALLSAAVGGRVNDPLALMAAARAMEREDICNCMDVQSVA
SEVAQAAEASSSSIRVESAKLDRLVGFVGELVILQSRLSQLVRGVPDDAMREVAEGLERL
AGSLRDSAMSMRMVPMGSTFHSFRRLVRDLAAQLGKKVLFEAEGGDTELDKTLIDQLRDP
LLHLLRNAMDHGIEPPEVRLATGKPEEGVVRLGASHSGGEVHIYVSDDGAGVDLEKVRLR
AVAMGLIPPETEPDTATLLALLYVPGFTTAPGVSEISGRGVGMDVVHSAIAALRGSLDME
TTPGRGTTCHIRLPLTLAIIDGMRVLVGGDSYIVPLTMVEACLERFVDGAVRTVECIEYR
GRLIPCVSLRLLLGVPGEQPGYERVIVAGKEGHEVGFAVDAVVGLQQAVIKGVGNLCRNV
AWISGTTVDADGGISLILDVVQLIRFAVGSVGPEAHA