Protein Info for DVU1945 in Desulfovibrio vulgaris Hildenborough JW710

Name: oorA
Annotation: pyruvate ferredoxin oxidoreductase, alpha subunit, putative (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01855: POR_N
  • amino acids 23 to 255 (233 residues), 242.1 bits, E=1e-75
• PF02780: Transketolase_C
  • amino acids 282 to 347 (66 residues), 26.4 bits, E=8.7e-10
• PF17147: PFOR_II
  • amino acids 283 to 377 (95 residues), 92.1 bits, E=3.9e-30

Best Hits

KEGG orthology group: K00174, 2-oxoglutarate ferredoxin oxidoreductase subunit alpha [EC: 1.2.7.3] (inferred from 100% identity to dvl:Dvul_1223)

MetaCyc: 51% identical to 2-oxoglutarate ferredoxin oxidoreductase alpha subunit (Methanococcus maripaludis)
2-oxoglutarate synthase. [EC: 1.2.7.3]

Predicted SEED Role

"2-oxoglutarate oxidoreductase, alpha subunit (EC 1.2.7.3)" (EC 1.2.7.3)

MetaCyc Pathways

• reductive TCA cycle I (9/11 steps found)
• incomplete reductive TCA cycle (6/7 steps found)
• TCA cycle V (2-oxoglutarate synthase) (7/9 steps found)
• TCA cycle VI (Helicobacter) (7/9 steps found)
• TCA cycle VII (acetate-producers) (6/9 steps found)
• reductive TCA cycle II (7/12 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (22/56 steps found)

KEGG Metabolic Maps

• Citrate cycle (TCA cycle)
• Reductive carboxylate cycle (CO2 fixation)

Isozymes

Compare fitness of predicted isozymes for: 1.2.7.3

Use Curated BLAST to search for 1.2.7.3

Sequence Analysis Tools

See Q72AP7 at UniProt or InterPro

Protein Sequence (382 amino acids)

>DVU1945 pyruvate ferredoxin oxidoreductase, alpha subunit, putative (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MALQLKRRKRRELFALGNEAVAEGALLAGCTFYAGYPITPSTEIMEVMAARLPRMEDGVF
IQMEDEIASMGAAIGASLAGRKAMTATSGPGFSLMQEHIGYACMVEAPLVIVNVMRGGPS
TGLPTCPAQGDVQMARWGTHGDHPIIVLSASNVQECLEMTVTAFNYAEKYRTPVILLIDE
VTAHTREKIIVPHAEELEIISRVEPTVPPEWFKPYADTVRGVPAMPAIGSGYRMHVTGLT
HDVMGYPTQRPDEVKDMMLRLFRKIDQFYGDIQLTDSFALEDAEVAVIAYGSVARSAHLA
VEQARERGAKAGLLTLKTLFPFPRPAVETLARRCSILVVPEMNMGQMSREVKRVNNGHAR
VRTINRVDGQIITPSEILKMLL