Protein Info for DVU1927 in Desulfovibrio vulgaris Hildenborough JW710

Name: ileS
Annotation: isoleucyl-tRNA synthetase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 938 TIGR00392: isoleucine--tRNA ligase" amino acids 14 to 848 (835 residues), 917.9 bits, see alignment E=3.3e-280 PF00133: tRNA-synt_1" amino acids 28 to 646 (619 residues), 452 bits, see alignment E=6.5e-139 PF09334: tRNA-synt_1g" amino acids 58 to 201 (144 residues), 43 bits, see alignment E=9.4e-15 amino acids 582 to 648 (67 residues), 22.8 bits, see alignment 1.3e-08 PF13603: tRNA-synt_1_2" amino acids 300 to 353 (54 residues), 30.6 bits, see alignment 8.2e-11 PF01406: tRNA-synt_1e" amino acids 594 to 652 (59 residues), 31.7 bits, see alignment 3.8e-11 PF08264: Anticodon_1" amino acids 689 to 846 (158 residues), 78.9 bits, see alignment E=1.4e-25 PF06827: zf-FPG_IleRS" amino acids 903 to 930 (28 residues), 35.7 bits, see alignment (E = 2e-12)

Best Hits

Swiss-Prot: 100% identical to SYI_DESVH: Isoleucine--tRNA ligase (ileS) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K01870, isoleucyl-tRNA synthetase [EC: 6.1.1.5] (inferred from 100% identity to dvu:DVU1927)

Predicted SEED Role

"Isoleucyl-tRNA synthetase (EC 6.1.1.5)" (EC 6.1.1.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72AR5 at UniProt or InterPro

Protein Sequence (938 amino acids)

>DVU1927 isoleucyl-tRNA synthetase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MSDYKKTLQLPETKFPMKANLTQREPEMLRKWEKDDAYGAMVRASGQQGTYVLHDGPPYA
NGNIHMGHALNKILKDIIVKSRNLQGFKAEYVPGWDCHGLPIELKVEHELGEKKRTMPAH
AVRKRCRQYAEKYLDIQRKEFKRLGVFGAWDKPYVTMHPSYEAATARELGNFAAKGGLVR
SKKPIYWCCSCQTALAEAEVEYHDHTSPSVHVRFPLRDPRVAEVLPGVDPAHAYIVIWTT
TPWTLPDNMAVAVHPDFDYVVVRHGGDFHIVAEGLLEACLKAFKWDEHEVVARIGGRALE
GLKATHPFYDRPSPIVLADYVTLESGTGCVHTAPGHGREDYETGLRYGLDIYSPLTDEGR
YLDCVEFFAGMTIFEANPKVIEKLREVGNLLAEGRITHSYPHCWRCKKPVIFRATTQWFI
AMERNDLRQKALDAIRDDVRWIPSWGQERIHNMIEFRPDWCISRQRMWGVPIVALLCEDC
GEAWNDADWMRDIAERFAKHATGCDYWYETDLSDIVPAGLRCPKCGGDHWKKETDILDVW
FDSGTSFAAVVEQREECGFPADLYLEGSDQHRGWFHSSLLASIGTRGVPPYRSVLTHGYV
VDGDGRKMSKSVGNVVAPQEIIDKHGAEVLRLWVASVDYREDIRISEEILNRLVDAYRRI
RNTCRYLLGNISDLTPETMVPFEAMDPLDRFALDLASRAHERIQDAYTEYEFHKVFHTLH
NLCVTDLSAFYLDILKDRLYSSAADSHARRSAQTALYRILMLMVRDMAPVLSFTAEEVFG
YVPAALRPDVISVFALPATDAPAFTLDTTSRAAWEKLLAVRSETTKAIEPLRKSGEVGHS
LDTHVTLFADPSLKATLEGLGSDLRAMFIVSRLEVMDLADAPADAWTSEELPELKVTVRK
AEGEKCERCWIISADLGTDAAHPTLCPRCTAVLTGTGA