Protein Info for DVU1411 in Desulfovibrio vulgaris Hildenborough JW710

Name: thiC
Annotation: thiamine biosynthesis protein ThiC (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 PF01964: ThiC_Rad_SAM" amino acids 7 to 422 (416 residues), 560.6 bits, see alignment E=1.1e-172 TIGR00190: phosphomethylpyrimidine synthase" amino acids 8 to 423 (416 residues), 488.4 bits, see alignment E=8.5e-151

Best Hits

Swiss-Prot: 49% identical to THIC_DESHD: Phosphomethylpyrimidine synthase (thiC) from Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)

KEGG orthology group: K03147, thiamine biosynthesis protein ThiC (inferred from 100% identity to dvu:DVU1411)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72C73 at UniProt or InterPro

Protein Sequence (429 amino acids)

>DVU1411 thiamine biosynthesis protein ThiC (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MSILNSNAALRGLLDQHLADLSREEGLAPETIRDAIERGTMVLLGNPSHPSLRPILVGQP
ARVKVNANIGTSPMRNHPECEMQKVDAAVEAGADTIMDLSIAGDLDAIRREMLARCPLPL
GTVPLYSVAQKYIECGKDPALIDPEEIFAEIEKQAQQGVDFMTVHCGLTRRGAEWAAKGD
RLLGIVSRGGSILARWMLRHDRENPLLTGYDRILDIARKYNVTLSLGDGLRPGAGADAGD
AAQWEEVMVLGQLAKRGLEAGVQCMIEGPGHVPMNEVEAQIVGIKKLTHGAPLYVLGPLV
IDSCPGYDHIAGAIGGALAVRSGVDFLCYLTPAEHLTLPTREDVRAGVIASRIAAQAGEV
ALGRPHALARELGMGKARKALDWPGMERHALDAAMVDERRGEHRNEEECAMCGKFCAVKM
LRDDPQGAF