Protein Info for DVU1201 in Desulfovibrio vulgaris Hildenborough JW710

Name: ribD
Annotation: riboflavin biosynthesis protein RibD (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 377 PF00383: dCMP_cyt_deam_1" amino acids 8 to 104 (97 residues), 68.9 bits, see alignment E=4.8e-23 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 9 to 370 (362 residues), 290.5 bits, see alignment E=9.3e-91 PF14437: MafB19-deam" amino acids 23 to 109 (87 residues), 34.3 bits, see alignment E=3.1e-12 PF01872: RibD_C" amino acids 151 to 369 (219 residues), 133.1 bits, see alignment E=1.7e-42

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 100% identity to dvu:DVU1201)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72CT2 at UniProt or InterPro

Protein Sequence (377 amino acids)

>DVU1201 riboflavin biosynthesis protein RibD (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MGPDFTPFMREAIALAERGRWYAAPNPTVGAVLVRDGEVAARGWHTGYGKPHAEVECLRD
AASKGVDPAHCTLVVTLEPCNHHGKTPPCSHAIVEAGITRVVVGLADPNPVASGGAEYLR
AHGVTVDMGVCEQECHDLVADFLTWKLTDLPYVILKLASTLDGRIATRSGHSQWISGAEA
RAAVHELRARIGEAGGAVLVGGTTLYTDDPQLTARVAPLPRRQPMAVVATRHVPHHDALP
RIFRERPGQCVVWTDSTGAGTEAADALRTSGVCIMALPLTPSGRLDLRAGLTRLRADHGV
EHVLCEGGGKLALSLLEAGLVGEFHLHMAPKIIGDAEAALLFDGRAPLHMDEALRLRMTG
IERRGDDCIMILRPGKG