Protein Info for DVU1079 in Desulfovibrio vulgaris Hildenborough JW710

Name: trmE
Annotation: tRNA modification GTPase TrmE (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 PF10396: TrmE_N" amino acids 6 to 124 (119 residues), 138.7 bits, see alignment E=2.6e-44 TIGR00450: tRNA modification GTPase TrmE" amino acids 11 to 457 (447 residues), 334.6 bits, see alignment E=1.1e-103 PF12631: MnmE_helical" amino acids 127 to 454 (328 residues), 138.9 bits, see alignment E=6.5e-44 PF02421: FeoB_N" amino acids 223 to 341 (119 residues), 36.4 bits, see alignment E=9.5e-13 PF01926: MMR_HSR1" amino acids 223 to 335 (113 residues), 80 bits, see alignment E=3.7e-26 TIGR00231: small GTP-binding protein domain" amino acids 223 to 342 (120 residues), 68.4 bits, see alignment E=6.3e-23

Best Hits

Swiss-Prot: 100% identical to MNME_DESVH: tRNA modification GTPase MnmE (mnmE) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K03650, tRNA modification GTPase (inferred from 100% identity to dvl:Dvul_1915)

Predicted SEED Role

"GTPase and tRNA-U34 5-formylation enzyme TrmE" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72D51 at UniProt or InterPro

Protein Sequence (457 amino acids)

>DVU1079 tRNA modification GTPase TrmE (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MQHDDTIAAIATPLGQGGIGIIRISGPASLEVLRALFRPSSSRFGGFRPWTLHHGTITDG
CDPLDDVLAVHMPGPRTFTGEDVSEIHCHGGSGVLAAVLEACVRHGARYAERGEFTRRAF
LNGRMDLTQAEAVAEMIAAPSREGMRLAQAKLDGLLGQRVGALRARLDALRMQLCVAVDF
PEEEVECLAPEAFLAEIEAVRQGVVELSAGYARTRCWQDGALVVLAGQVNAGKSSLMNAL
LGRRRAIVTDLPGTTRDFIEEPLNLSGLAIRLADTAGLRETGDIVEQEGVRMSRDLVAQA
DLVLLVTDATQGLQGPELELLRHAGPERVLVVFNKTDLLEGRILPSTPEGCRSVHVAAAS
GDGVESLVTAIRAAVLAATGAGEPEAGELAPNMRQAAALDKAATILDELAGDIRAHVPYD
LCGVRLDGACAALMDVTGQSTPEAILDAIFASFCIGK