Protein Info for DVU1066 in Desulfovibrio vulgaris Hildenborough JW710

Name: gpt
Annotation: xanthine-guanine phosphoribosyltransferase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00156: Pribosyltran
  • amino acids 15 to 152 (138 residues), 65.8 bits, E=1.5e-22

Best Hits

Swiss-Prot: 100% identical to XGPT_DESVH: Xanthine phosphoribosyltransferase (gpt) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K00769, xanthine phosphoribosyltransferase [EC: 2.4.2.22] (inferred from 99% identity to dvl:Dvul_1928)

MetaCyc: 56% identical to xanthine-guanine phsophoribosyltransferase (Escherichia coli K-12 substr. MG1655)
Hypoxanthine phosphoribosyltransferase. [EC: 2.4.2.8]; 2.4.2.8 [EC: 2.4.2.8]; Xanthine phosphoribosyltransferase. [EC: 2.4.2.8, 2.4.2.22]

Predicted SEED Role

"Xanthine-guanine phosphoribosyltransferase (EC 2.4.2.22)" in subsystem Purine conversions (EC 2.4.2.22)

MetaCyc Pathways

• superpathway of purine nucleotide salvage (13/14 steps found)
• guanine and guanosine salvage I (2/2 steps found)
• xanthine and xanthosine salvage (2/2 steps found)
• adenine and adenosine salvage III (3/4 steps found)
• adenine salvage (2/3 steps found)
• superpathway of guanine and guanosine salvage (2/3 steps found)
• guanine and guanosine salvage II (1/2 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.8

Use Curated BLAST to search for 2.4.2.22 or 2.4.2.8

Sequence Analysis Tools

See Q72D63 at UniProt or InterPro

Protein Sequence (163 amino acids)

>DVU1066 xanthine-guanine phosphoribosyltransferase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MSTADRYRKVFPVTWEQLHRDAKALSWRLLEKGPYKGIIAIARGGLVPAAVIARELDIHL
VETICISSYQWQEQTSSHKVLKTVEGRGEGWLIIDDLADTGGTARLVREMLPEAHFATVY
AKPAGRPLVDTFITEVSQDTWILFPWDSEVQYVVPLVNQPQQS