Protein Info for DVU0866 in Desulfovibrio vulgaris Hildenborough JW710

Name: dxr
Annotation: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00243: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • amino acids 20 to 397 (378 residues), 447.9 bits, E=1.4e-138
• PF02670: DXP_reductoisom
  • amino acids 21 to 148 (128 residues), 137.2 bits, E=8.1e-44
• PF08436: DXP_redisom_C
  • amino acids 162 to 245 (84 residues), 132.3 bits, E=8.6e-43
• PF13288: DXPR_C
  • amino acids 277 to 393 (117 residues), 135.1 bits, E=2.1e-43

Best Hits

Swiss-Prot: 100% identical to DXR_DESVH: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K00099, 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC: 1.1.1.267] (inferred from 100% identity to dvu:DVU0866)

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267)" in subsystem Isoprenoid Biosynthesis or polyprenyl synthesis (EC 1.1.1.267)

MetaCyc Pathways

• methylerythritol phosphate pathway II (9/9 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (10/12 steps found)
• taxadiene biosynthesis (engineered) (10/13 steps found)
• methylerythritol phosphate pathway I (7/9 steps found)
• isoprene biosynthesis I (7/10 steps found)
• superpathway of ergosterol biosynthesis II (9/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.267

Sequence Analysis Tools

See Q72DR3 at UniProt or InterPro

Protein Sequence (408 amino acids)

>DVU0866 1-deoxy-D-xylulose 5-phosphate reductoisomerase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MIRYISAMPSPEWEHETPRTLALLGSTGSIGTSALRVVEAHPHRFKVVALAGARNVEKLA
AQAARWRPEHLGVLDATGAAKLRDLLPAGYAPHIHIGPEGYATMATLPEAGTVLSAQVGA
AGLRATEAAARHGKVICLANKESLVLAGDIIRRHCAGSGAVILPVDSEHNAIFQALQGHD
PASVRRIILTASGGPFRGRSRDDLAAVSCRDALAHPNWNMGAKISIDSATLMNKGLEVIE
ACHLYGVGIDDVGVVVHPQSIVHSLVEYEDGSQIAHLGTPDMRIAIAYCLTWPGVVDAGV
PRLDLVKAGSLTFEEPDLHSFPCLELARRAYREGRGMPVVLNAANEVAVSLFLSDRIRFL
DIPDIIARALDMHDGTTPHDIEGIEALDEATRRTVYERAGHSNTDGMA