Protein Info for DVU0796 in Desulfovibrio vulgaris Hildenborough JW710

Name: hisD
Annotation: histidinol dehydrogenase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 436 PF00815: Histidinol_dh" amino acids 28 to 432 (405 residues), 545.4 bits, see alignment E=4.8e-168 TIGR00069: histidinol dehydrogenase" amino acids 35 to 432 (398 residues), 523.6 bits, see alignment E=1.9e-161

Best Hits

Swiss-Prot: 100% identical to HISX_DESVH: Histidinol dehydrogenase (hisD) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 100% identity to dvu:DVU0796)

MetaCyc: 39% identical to sulfopropanediol 3-dehydrogenase monomer (Cupriavidus pinatubonensis JMP134)
RXN-11727 [EC: 1.1.1.308]

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23 or 1.1.1.308

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P62457 at UniProt or InterPro

Protein Sequence (436 amino acids)

>DVU0796 histidinol dehydrogenase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPCRILTLQSEAQWPLLGDMLAGRYDPDDAVEPVVRDILAAVRSKGDEALAEYTRRFDCP
DFTPALLHVTSEEVAQAVASVPADDIAIIRQAADNIRSFHEAQKERSWFVTHDDGTILGQ
KVTPVDRAGLYVPGGKGGDTPLLSSLLMNAIPAQVAGVTSITVASPPRPDGTLNPHLLAA
AHILGITDIIRAGSAWAVAAFAFGTQTIAPVDVIAGPGNIFVTTAKRMVQGRVAIDMIAG
PSEILILADATARPDWVAADMLSQAEHDPLASSILVTTEPALAEAVTAELERQLATLPRA
DIARKALADWGAVVVVPDMDVAVAIANRVAPEHLEVLTAQPWELAGSLRHAGALFLGPYS
PEPLGDYFAGPNHVLPTMGTARFSSALSVQTFCKRTSIIAASRAFAERNADAVARLARLE
GLEAHARSAASRNSQQ