Protein Info for DVU0734 in Desulfovibrio vulgaris Hildenborough JW710

Name: cysG-1
Annotation: uroporphyrinogen III synthase/methyltransferase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00590: TP_methylase
  • amino acids 2 to 214 (213 residues), 169.9 bits, E=7.6e-54
• TIGR01469: uroporphyrinogen-III C-methyltransferase
  • amino acids 2 to 238 (237 residues), 308.3 bits, E=2.1e-96
• PF02602: HEM4
  • amino acids 266 to 493 (228 residues), 228.2 bits, E=7.8e-72

Best Hits

KEGG orthology group: K13542, uroporphyrinogen III methyltransferase / synthase [EC: 2.1.1.107 4.2.1.75] (inferred from 100% identity to dvl:Dvul_2236)

Predicted SEED Role

"Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75)" in subsystem Coenzyme B12 biosynthesis or Dissimilatory nitrite reductase or Experimental tye or Heme and Siroheme Biosynthesis (EC 2.1.1.107, EC 4.2.1.75)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (27/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
• cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (13/15 steps found)
• tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)
• siroheme biosynthesis (4/4 steps found)
• cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) (10/13 steps found)
• tetrapyrrole biosynthesis II (from glycine) (3/4 steps found)
• superpathway of heme b biosynthesis from glutamate (6/10 steps found)
• factor 430 biosynthesis (3/7 steps found)
• superpathway of heme b biosynthesis from glycine (3/8 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (3/26 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.107 or 4.2.1.75

Sequence Analysis Tools

See Q72E45 at UniProt or InterPro

Protein Sequence (503 amino acids)

>DVU0734 uroporphyrinogen III synthase/methyltransferase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MKVYLIGAGPGDPGLLTLKGKEILERADVVVYDFLANDAFLAYAKPDAEIIYVGKKGGDH
TLSQDGINRLIIEKAKEGKVVARLKGGDPYMFGRGGEEAEELLDAGVPFEEVPGVTSAIA
GPAYAGIPLTHRSYASSVSFITGHENPDKPDSAHNWQALAAGTSTLVFFMGMKNLPDISR
KLIAAGMSPDKPAALVRWGTTPRHRSLVATIATLPEEAVKHGFSNPSLIVVGDVVRLRDR
LNWFEHKPLLGKGVVVTRAREQASGLAAALRELGADVIQFPTIDIHPLDDYAPVHEAIRA
LDTYDWVVFTSVNGVKHFWNQLAALGLDSRALGGRKVAAIGPATADALRDKGIAPDFIPE
KYVAEGVVEGMLARGMGGKRVLLPRALEAREVLPEELRKAGATVDVLPVYVTVPSAARRD
DVLARMEAGEVHCVTFGSSSTVENFFSLVPADTVKAHPEVKLACIGPVTKKTLEGFGFTC
HIQPDDYTIPALVDELTRVLPEL