Protein Info for SO4717 in Shewanella oneidensis MR-1

Annotation: sensor histidine kinase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 709 transmembrane" amino acids 21 to 47 (27 residues), see Phobius details amino acids 337 to 360 (24 residues), see Phobius details PF17201: Cache_3-Cache_2" amino acids 219 to 334 (116 residues), 38.9 bits, see alignment E=1.4e-13 PF17202: sCache_3_3" amino acids 219 to 335 (117 residues), 81.8 bits, see alignment E=8.7e-27 PF00512: HisKA" amino acids 468 to 532 (65 residues), 45.1 bits, see alignment E=1.7e-15 PF02518: HATPase_c" amino acids 579 to 684 (106 residues), 78.2 bits, see alignment E=1.4e-25

Best Hits

KEGG orthology group: K02482, two-component system, NtrC family, sensor kinase [EC: 2.7.13.3] (inferred from 100% identity to son:SO_4717)

Predicted SEED Role

"Signal transduction histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8E8E8 at UniProt or InterPro

Protein Sequence (709 amino acids)

>SO4717 sensor histidine kinase (NCBI ptt file) (Shewanella oneidensis MR-1)
MSFFTHFFGVSWQQMQAKVRYRILILTLLPILLTLVSLVFITIYWNISYTGKQLFMKVKA
DLAVAENTLQQVQVRQEKQLERVMTSWTFQNDFRPILSGALAHRASIDTFLHEQKKQLDL
DFLRLVSVAEAAADPDLRQILPKIGGMLPYSGLMVLSRERLARIDPDLAQRASIPLLATL
RAQSPDKQVEERGLLSRSLLPIPDSEGKVAWYLDGGVLFNRDTRIVDHIRDLVYDKGTLP
ERSIGTVTIFLDNIRVSTNVPLHFFPQPNESQGRALGSLVSEEVREKVLNHGELWVDRAF
VYNDWFISAYAPLEDIRGQRVGMIYTGFSESPFIHNYLLNIIELGTILMLVLLISGLLVY
RGAYSLLQPIERIHHVVQAVQSGRNVRIGALGLDRDNELSNLAEQFDRMLDLLQRRNAQI
QAAAEQLEMKVEERTRSLQDKTLELQRNVALLNETRQQLVTNEKLTALGELTAGIAHEIN
NPTAVILGNMELLRYELGDKAEVVKEEIDLVIQQVGRISTIIRSLLQYSRPGEFNAPLEM
HPITPIIEEMLVLVRHSIQKQEVVLITELNASCPVQVNRPQLLQVLINLVVNAAHAMDGK
GRIWVRTYDWVQQDIAIGVKIEVEDEGSGIEPEQLGRIFDPFYTTRKDGTGLGLSLSYGI
IKRIGGTIEVSSVLGKGSIFTIGLYHEAKEDHQNNPYDGLHFSGNHPES